N^(6)-甲基腺苷甲基化在射血分数保留性心力衰竭中的作用的研究进展

Role of N^(6)-Methyladenosine Methylation in Heart Failure with Preserved Ejection Fraction

表观遗传学参与心血管疾病进展的过程。近年研究表明,射血分数保留性心力衰竭(HFpEF)患者的多个基因转录本存在N^(6)-甲基腺苷(m^(6)A)水平的改变。现介绍m^(6)A及其调节因子(甲基化酶、去甲基化酶和甲基化阅读蛋白)与HFpEF的关系,说明m^(6)A可能通过影响心肌肥厚与纤维化、细胞自噬、炎症与氧化应激、糖脂代谢参与HFpEF的发生和发展,以期为HFpEF的治疗靶点提供新的研究方向。

Epigenetics is involved in the progression of cardiovascular disease.Recent studies have shown that there are changes in the level of N^(6)-methyladenosine(m^(6)A)in multiple gene transcripts in patients with heart failure with preserved ejection fraction(HFpEF).This article introduces the relationship between m^(6)A and its regulators(methylase,demethylase and methylated reading protein)and HFpEF,indicating that m^(6)A may participate in the occurrence and development of HFpEF by affecting myocardial hypertrophy and fibrosis,autophagy,inflammation and oxidative stress,glucose and lipid metabolism,in order to provide a new research direction for the therapeutic target of HFpEF.