天麦消渴片联合恩格列净治疗2型糖尿病的效果探讨

Discussion on Effect of Tianmai Xiaoke Tablets Combined with Empagliflozin in the Treatment of Type 2 Diabetes Mellitus

目的 探讨天麦消渴片联合恩格列净治疗2型糖尿病的临床效果。方法 选取2018年10月至2020年4月我院收治的75例2型糖尿病患者,随机分为观察组(n=38)和对照组(n=37)。在常规治疗基础上,观察组采用天麦消渴片联合恩格列净治疗,对照组仅采用恩格列净治疗,两组均连续治疗3个月。比较两组患者治疗前、治疗3个月后的血糖指标、胰岛素抵抗指数(HOMA-IR)及治疗期间不良反应发生情况。结果 治疗3个月后,两组的空腹血糖(FBG)、糖化血红蛋白(GHb)、HOMA-IR均低于治疗前,且观察组的FBG、 GHb、 HOMA-IR低于对照组(P<0.05)。治疗期间,两组的不良反应发生率(13.16%vs. 8.11%)比较,差异无统计学意义(P>0.05)。结论 天麦消渴片联合恩格列净治疗2型糖尿病效果显著,能有效减少胰岛素抵抗,控制患者血糖水平,且安全性较高。

Objective To explore the clinical effect of Tianmai Xiaoke tablets combined with enpagliflozin in the treatment of type 2 diabetes mellitus.Methods 75 patients with type 2 diabetes mellitus admitted to our hospital from October 2018 to April 2020 were selected and randomly divided into observation group(n=38)and control group(n=37).On the basis of conventional treatment,the observation group was treated with Tianmai Xiaoke tablets combined with empagliflozin,and the control group was only treated with empagliflozin.Both groups were treated continuously for 3 months.The blood glucose indicators and insulin resistance index(HOMA-IR)before treatment and after 3 months of treatment,and the adverse reactions during treatment were compared between the two groups.Results After 3 months of treatment,the fasting blood glucose(FBG),glycosylated hemoglobin(GHb)and HOMA-IR of the two groups were lower than those before treatment,and the FBG,GHb and HOMA-IR of the observation group were lower than those of the control group(P<0.05).During treatment,no statistical difference was found in the incidence of adverse reactions(13.16%vs.8.11%)between the two groups(P>0.05).Conclusions Tianmai Xiaoke tablets combined with enpagliflozin has significant effect in the treatment of type 2 diabetes mellitus,which can effectively reduce the insulin resistance,and control patients'blood glucose level,with higher safety.