布地奈德、特布他林雾化对小儿支气管炎的临床治疗作用

Clinical Effect of Nebulization of Budesonide and Terbutaline on Bronchitis in Children

目的研究布地奈德、特布他林雾化对小儿支气管炎的临床治疗作用。方法方便选取2018年9月—2020年5月来南京市浦口区中心医院接受治疗的小儿支气管炎患儿80例为研究对象,经抽签法分为对照组、观察组,各40例。所有患儿均接受常规治疗,对照组加用地塞米松治疗,观察组加用布地奈德、特布他林雾化治疗。观察两组患儿疗效、免疫功能、动脉血气指标及不良反应。结果观察组临床、有效率(95.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.114,P=0.043);观察组咳嗽、气促、湿啰音以及肺部X线阴影症状消失时间短于对照组,差异有统计学意义(P<0.05);观察组免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)与补体C3水平高于对照组,差异有统计学意义(P<0.05);观察组动脉血氧分压(PaO_(2))、水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率12.50%(5/40)与对照组32.50%(13/40)比较,差异有统计学意义(P<0.05)。结论小儿支气管炎应用布地奈德、特布他林雾化治疗能积极改善患儿临床疗效,提升其免疫功能,促进血气指标恢复,且用药安全,临床应用价值高。

Objective To study the clinical therapeutic effect of budesonide and terbutaline atomization on bronchitis in children.Methods 80 children with pediatric bronchitis who came to Nanjing Pukou District Central Hospital for treatment from September 2018 to May 2020 were conveniently selected as the research objects.They were divided into a control group and an observation group by lottery,with 40 cases in each group.All children received conventional treatment.The control group was treated with dexamethasone,and the observation group was treated with budesonide and terbutaline atomization.Observed the curative effect,immune function,arterial blood gas index and adverse reactions of the two groups of children.Results The efficiency(95.00%)of the observation group were higher than those in the control group(80.00%),the difference was statistically significant(χ^(2)=4.114,P=0.043).The disappearance time of cough,shortness of breath,wet rale,and X-ray lung shadow symptoms of the observation group were shorter than that in the control group,the difference was statistically significant(P<0.05).The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)and complement C3 of the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The levels of arterial oxygen pressure(PaO_(2))of the observation group were higher than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions of 12.50%(5/40)in the observation group was compared with 32.50%(13/40)in the control group,the difference was statistically significant(P<0.05).Conclusion The application of budesonide and terbutaline atomized treatment for children with bronchitis can positively improve the clinical efficacy of children,enhance their immune function,and promote the recovery of blood gas indicators.The medication is safe and has high clinical application value.