曲霉菌感染在支气管扩张症中的作用及其诊断与治疗

Role of aspergillus infection in bronchiectasis and its diagnosis and treatment

支气管扩张症是以支气管异常扩张为特征的一类异质性疾病,表现为咳嗽、咳痰及反复出现的肺部感染。曲霉菌作为肺部感染的常见真菌之一,在支气管扩张症中既可作为疾病的结局出现,也可作为诱因参与疾病进展,最终使支气管扩张症的病程复杂化。该文对支气管扩张症中的曲霉菌易感因素及致病机制进行阐述,并进一步介绍了支气管扩张症合并曲霉菌感染的诊断及治疗现状,旨在明确曲霉菌感染在支气管扩张症中的作用,并为其临床诊治提供新的思考方向。

Bronchiectasis is a heterogeneous disease characterized by abnormal expansion of the bronchi,manifested by cough,sputum,and recurring lung infections.As one of the common fungi of lung infection,aspergillus can not only appear as the outcome of the disease in bronchiectasis,but also as an inducement to participate in the disease progression,and ultimately complicate the course of bronchiectasis.This article describes the susceptibility factors and pathogenic mechanisms of aspergillus in bronchiectasis,and further introduces the diagnosis and treatment status of bronchiectasis combined with aspergillus infection,aiming to clarify the effect of aspergillus infection on bronchiectasis and provide new thinking directions for its clinical diagnosis and treatment.