高脂血症性急性胰腺炎的治疗进展

Progress in the treatment of hyperlipidemia acute pancreatitis

近年来,高脂血症性急性胰腺炎(hyperlipidemia acute pancreatitis,HLAP)的发病率逐年升高,其发病机制尚未完全明确。临床上关于HLAP的治疗方法有很多,包括降脂药物、低分子肝素、胰岛素、血浆置换等,其中积极降低血清中甘油三酯是治疗的核心,血浆置换可迅速有效降低甘油三酯水平,在HLAP的治疗中应用逐渐增多。该文就近年来国内外关于HLAP的发病机制、临床特征、诊断和治疗进展进行了综述,重点讨论了血浆置换治疗HLAP的作用机制、指征、时机以及不足。

In recent years,the incidence of hyperlipidemia acute pancreatitis(HLAP)has been increasing year by year,but its pathogenesis has not been completely clear.There are many clinical treatment methods for HLAP,such as lipid-lowering drugs,low molecular weight heparin,insulin,and plasma exchange.Actively reducing serum triglyceride is the core of treatment.Plasma exchange can quickly and effectively reduce the level of triglyceride,and its application in the treatment of HLAP is gradually increasing.This article reviews the recent advances in the pathogenesis,clinical characteristics,diagnosis,and treatment of HLAP,focusing on the mechanism,indications,timing,and disadvantages of plasma exchange therapy for HLAP.