益生菌调控质子泵抑制剂所致消化道微生态紊乱的应用价值探讨

Application value of probiotics in regulating proton pump inhibitor-induced gastrointestinal microecological disorders

质子泵抑制剂(proton pump inhibitor,PPI)在消化系统疾病中应用广泛,但其长期应用可能引起艰难梭菌感染、小肠细菌过度生长、自发性腹膜炎以及胃肠道屏障功能障碍。益生菌能通过抑制细菌在肠道的定植、调节机体免疫、降低肠道pH值以及增强肠黏膜的屏障功能等途径改善PPI应用过程中引起的消化道微生态紊乱。该文从PPI对消化道微生态的影响以及益生菌对消化道微生态的调控作用作一阐述,旨在为临床中PPI应用引起的消化道微生态紊乱及其干预策略提供一定思路。

Proton pump inhibitors(PPIs)are widely used in digestive system diseases,but long-term use of PPI may cause Clostridium difficile infection,small intestinal bacterial overgrowth,spontaneous bacterial peritonitis and gastrointestinal barrier dysfunction.Probiotics can improve the digestive tract microecological disorder caused by the application of PPI by inhibiting the colonization of bacteria in the intestinal tract,regulating the body’s immunity,reducing the pH value of the intestinal tract,and enhancing the barrier function of the intestinal mucosa.This article elaborates on the influence of PPI on the microecology of the digestive tract and the regulation of probiotics on the microecology of the digestive tract,aiming to provide some ideas for the digestive tract microecological disorders caused by the application of PPI in clinical practice and their intervention strategies.