雷公藤多苷片治疗干燥综合征的临床效果

Clinical effect of Tripterygium Glycoside Tablets in treating Sjogren′s syndrome

目的探讨雷公藤多苷片治疗干燥综合征的临床效果。方法选取2020年1月至2021年5月赣南医学院第一附属医院收治的60例干燥综合征患者作为研究对象,按照随机数字表法分为对照组(30例)与观察组(30例)。对照组采用泼尼松+硫酸羟氯喹治疗,观察组联合雷公藤多苷片治疗。比较两组的临床疗效、IgG、类风湿因子(RF)水平及临床症状改善情况、不良反应发生率。结果观察组的临床疗效高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的IgG、RF水平低于对照组,差异有统计学意义(P<0.05)。观察组的唾液流量、泪流率高于对照组,数字评估量表(NRS)评分低于对照组,差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论雷公藤多苷片治疗干燥综合征的疗效显著,可有效改善患者口干、眼干、关节痛症状及免疫功能、RF水平。

Objective To explore the clinical effect of Tripterygium Glycoside Tablets in the treatment of Sjogren′s syndrome.Methods From January 2020 to May 2021,60 patients with Sjogren′s syndrome admitted to the First Affiliated Hospital of Gannan Medical College were selected as the research objects,and they were divided into the control group(30 cases)and the observation group(30 cases)according to the random number table method.The control group was treated with Prednisone+Hydroxychloroquine Sulfate,and the observation group was treated with Tripterygium Glycoside Tablets.The clinical efficacy,the levels of immunoglobulin,rheumatoid factor,improvement of clinical symptoms,and the incidence of adverse reactions between the two groups were compared.Results The clinical efficacy of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IgG and rheumatoid factor(RF)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The saliva flow rate and tear flow rate of the observation group were higher than those of the control group,and the numerical evaluation scale(NRS)score of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Tripterygium Glycoside Tablets are effective in treating Sjogren′s syndrome.They can effectively improve the symptoms of dry mouth,dry eyes,and joint pain,as well as immune function and rheumatoid factor levels.