艾司奥美拉唑联合马来酸曲美布汀治疗老年性胃食管反流病的效果

Effect of Esomeprazole combined with Trimebutine Maleate in the treatment of geriatric gastroesophageal reflux disease

目的探讨艾司奥美拉唑联合马来酸曲美布汀治疗老年性胃食管反流病的效果。方法选取2018年2月至2020年2月深圳市龙岗中心医院收治的84例老年性胃食管反流病患者作为研究对象,按照随机数字表法分为研究组(42例)与对照组(42例)。研究组采用艾司奥美拉唑联合马来酸曲美布汀治疗,对照组采用艾司奥美拉唑单药治疗,两组均持续用药8周。比较两组治疗前后的症状积分、生活质量评分、胃镜下疗效及血清胃动素、胃泌素-17水平。结果治疗前,两组的症状积分及生活质量评分比较,差异无统计学意义(P>0.05)。治疗后,两组的症状积分低于治疗前,生活质量评分高于治疗前,且研究组的症状积分低于对照组,生活质量评分高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组的胃镜下总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组的血清胃动素及血清胃泌素-17水平比较,差异无统计学意义(P>0.05)。治疗后,两组的血清胃动素水平高于治疗前,血清胃泌素-17水平低于治疗前,且研究组的血清胃动素水平高于对照组,血清胃泌素-17水平低于对照组,差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论艾司奥美拉唑联合马来酸曲美布汀治疗老年性胃食管反流病的效果确切,可有效改善临床症状,提高生活质量。

Objective To explore the effect of Esomeprazole combined with Trimebutin Maleate in the treatment of geriatric gastroesophageal reflux disease.Methods A total of 84 patients with geriatric gastroesophageal reflux disease admitted to Longgang Central Hospital of Shenzhen City from February 2018 to February 2020 were selected as the research subjects,and they were divided into the study group(42 cases)and the control group(42 cases)according to random number table method.The study group was treated with Esomeprazole combined with Trimebutin Maleate,while the control group was treated with Esomeprazole monotherapy.Both groups were treated for 8 weeks.Symptom score,quality of life score,gastroscopic efficacy,the level of serum motilin and gastrin-17 were compared between the two groups before and after treatment.Results There were no statistical significance in the symptom scores and quality of life scores of the two groups before treatment(P>0.05).After treatment,symptom score of the two groups were lower than those before treatment,quality of life score of the two groups were higher than those before treatment,and the symptom score of the study group was lower than the control group,quality of life score of the study group was higher than the control group,the differences were statistically significant(P<0.05).After treatment,the total effective rate under gastroscopy in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of serum motilin and serum gastrin-17 between the two groups(P>0.05).After treatment,the levels of serum motilin in the two groups were higher than those before treatment,and the levels of serum gastrin-17 in the two groups were lower than those before treatment,and the level of serum motilin in the study group was higher than that in the control group,and the level of serum gastrin-17 in the study group was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Esomeprazole combined with Trimebutin Maleate in the treatment of geriatric gastroesophageal reflux disease is effective,which can effectively improve the clinical symptoms,improve the quality of life.