摘要
Hepatocellular carcinoma(HCC),which is the most frequent primary liver malignancy,is ranked as the sixth most common cancer and the third leading cause of cancer-related deaths worldwide,with its incidence expected to continue rising.One of the reasons is that most patients are diagnosed at an advanced stage when therapeutic options are ineffective.The development of HCC is attributed to a chronic exposition to either one or a combination of low amounts of different hepatotoxins,such as in hepatitis virus infection,alcohol consumption,aflatoxin from contaminated foods,metabolic factors,and exposure to chemical carcinogens from tobacco smoke(Fomer et al.,2018).
基金
funded by the National Council of Science and Technology(CONACYT
No.CF2019-53358)
the National Institute of Genomic Medicine(INMEGEN
No.06/2017/I)
the Unit of Production and Experimentation of Laboratory Animals of Center for Research and Advanced Studies of the National Polytechnic Institute(UPEAL-CINVESTAV-IPN
No.0114-14)
the Autonomous University of Hidalgo State(UAEH
No.SEP-PFCE 2018)
CONACYT-Mexico for awarding the masters(No.484737)
doctoral fellowships(No.752715)
CONACYT-Mexico for awarding the doctoral fellowship(No.431419)
the Cátedras-CONACYT program。
