结直肠癌脑转移诊治研究进展

Progress in diagnosis and treatment of brain metastasis from colorectal cancer

目的阐述结直肠癌脑转移患者的临床病理特征,综述其诊断和治疗进展,为我国结直肠癌脑转移患者的全程管理提供参考。方法对结直肠癌脑转移的最新研究结果和既往文献进行综述。结果结直肠癌脑转移患者预后较差,其分子病理机制复杂多样,已发现一些与结直肠癌脑转移发生相关的危险因素。结直肠癌脑转移的典型影像学特征有助于对其诊断。目前,放射治疗仍然是结直肠癌脑转移患者的主要治疗手段,贝伐珠单抗治疗、免疫治疗联合放射治疗有望提高结直肠癌脑转移患者的生存率及延长生存期。结论科学规范的预防和诊治有利于降低结直肠癌脑转移发病率和提高患者生存率。

Objective To elucidate the clinical and pathological features and review the progress of diagnosis and treatment in patients with brain metastasis(BM) from colorectal cancer(CRC), so as to provide a reference for the whole process management for patients with BM from CRC in China. Method The latest research results and previous literatures about patients with BM from CRC were reviewed. Results The prognosis of BM from CRC was poor, its molecular pathological mechanism was complex and diverse, and some risk factors associated with the occurrence of BM had been identified. Typical imaging features of BM from CRC were helpful to the diagnosis of patients. At present,radiotherapy was still the main treatment. Bevacizumab treatment or immunotherapy combined with radiotherapy was expected to improve the survival of BM from CRC. Conclusion Scientific and standardized prevention, diagnosis, and treatment are beneficial to reduce incidence of BM from CRC and improve survival.