乙型肝炎病毒基因型与肝细胞癌发生关系的研究现状

Research status of relationship between hepatitis B virus genotypes and hepatocarcinogenesis

目的总结目前国内外对乙型肝炎病毒X蛋白(HBx)、乙型肝炎病毒(HBV)基因亚型和肝细胞癌三者之间关系的研究现状,并对其在临床工作中的意义进行展望。方法查阅近年来国内外关于HBx、HBV基因亚型和肝细胞癌研究的相关文献并加以综述。结果 HBx和肝细胞癌的发生、发展、迁徙以及转移之间有着密切的关系,HBV基因亚型与肝细胞癌存在一定的关联,但具体机制尚未阐明。结论 HBx和HBV基因亚型在肝细胞癌的发生发展过程中扮演着重要的角色,随着分子机制的不断深入研究,必将推动乙型肝炎、肝硬化和肝细胞癌的诊治工作,为临床工作者提供更为个体化的干预手段。

Objective To summarize the research status of the relationship between hepatitis B virus X protein(HBx), hepatitis B virus(HBV) genotypes and hepatocellular carcinoma(HCC) at home and abroad, and to prospect its clinical significance. Method The literatures about HBx, HBV genotypes and HCC were reviewed. Results There was a close relationship between HBx and the occurrence, development, migration and metastasis of HCC. There was a certain association between HBV genotypes and HCC, but the specific mechanism had not been clarified. Conclusions HBx and HBV genotypes play an important role in the occurrence and development of HCC. With the further study of molecular mechanism, it will promote the diagnosis and treatment of hepatitis B, liver cirrhosis and liver cancer, and provide more individualized intervention for clinical workers.