重组干扰素α–2b联合布地奈德对毛细支气管炎患儿免疫功能的影响

Effects of Recombinant Interferon α-2b Combined with Budesonide on Immune Function in Children with Bronchiolitis

目的:探讨重组干扰素α–2b雾化联合布地奈德雾化治疗毛细支气管炎患儿及对其免疫功能的影响。方法:选取2018年1月至2019年1月在开封市儿童医院确诊的90例毛细支气管炎患儿,采用简单随机分组法将患儿分为观察组和对照组,各45例。对照组患儿采用布地奈德雾化治疗,观察组采用重组干扰素α–2b雾化联合布地奈德雾化治疗,均持续治疗1周。比较两组患儿的疗效,治疗前后的CD3^(+)、CD4^(+)及CD8^(+)水平,临床症状消失时间以及治疗期间的不良反应发生情况。结果:观察组患儿治疗的总有效率为93.33 %,高于对照组的77.78 %。治疗1周后,观察组患儿CD3^(+)、CD8^(+)水平明显高于对照组,CD4^(+)水平明显低于对照组。观察组患儿各临床症状消失时间均明显短于对照组,差异均具有统计学意义(P<0.05)。两组患儿治疗期间的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组干扰素α–2b雾化联合布地奈德雾化治疗毛细支气管炎患儿可以改善其免疫功能,促进机体恢复。

Objective To explore the effects of recombinant interferon α-2b combined with budesonide atomization on immune function of children with bronchiolitis.Methods A total of 90 children with bronchiolitis confirmed in Kaifeng Children’s Hospital were enrolled between January 2018 and January 2019.According to simple random grouping method,they were divided into observation group and control group,with 45 cases in each group.Children in the control group were treated with budesonide,while those in the observation group were treated with recombinant interferon α-2b combined with budesonide for aerosol inhalation.All were continuously treated for 1 week.The curative effect,levels of CD3^(+),CD4^(+)and CD8^(+)before and after treatment,the time when clinical symptoms disappeared and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group (93.33% vs 77.78%).After 1 week of treatment,levels of CD3^(+)and CD8^(+)in the observation group were significantly higher than those in the control group,while CD4^(+)level was significantly lower than that in the control group.The disappearance time of clinical symptoms in the observation group was significantly shorter than that in the control group (P < 0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P > 0.05).Conclusion Recombinant interferon α-2b combined with budesonide atomization can improve immune function and promote recovery of children with bronchiolitis.