喜炎平结合哌拉西林舒巴坦在社区获得性肺炎中的应用

Application of Xiyanping Combined with Piperacillin and Sulbactam in Community-Acquired Pneumonia

目的:探讨喜炎平注射液结合哌拉西林舒巴坦对社区获得性肺炎(CAP)患者症状改善及肺功能的影响。方法:选取台山市人民医院2018年12月至2019年12月期间收治的100例CAP患者,采用盲抽法将其分为对照组与观察组,各50例。对照组采用哌拉西林舒巴坦治疗,观察组在对照组基础上加用喜炎平注射液治疗,治疗1周后,比较两组患者的临床疗效、肺功能及临床症状改善情况。结果:观察组患者治疗总有效率为94.00 %,高于对照组的80.00 %,差异具有统计学意义(P<0.05)。治疗前,两组患者的用力肺活量(FVC)、第1秒用力呼气容积百分比(FEV1%)比较,差异无统计学意义(P>0.05);治疗后,两组患者的FVC、FEV1%均比治疗前高,且观察组高于对照组,差异具有统计学意义(P<0.05)。观察组患者的发热、咳嗽、胸闷消失时间均短于对照组,差异具有统计学意义(P<0.05)。结论:喜炎平注射液结合哌拉西林舒巴坦治疗CAP效果确切,可缩短临床症状缓解时间,改善肺功能。

Objective To explore the effect of Xiyanping injection combined with piperacillin and sulbactam on symptom improvement and lung function of patients with community-acquired pneumonia (CAP).Methods A total of 100 CAP patients admitted to Taishan People’s Hospital from December 2018 to December 2019 were selected and divided into a control group and an observation group,with 50 cases in each group.The control group was treated with piperacillin and sulbactam,and the observation group was treated with Xiyanping injection on the basis of the control group.After one week of treatment,the clinical efficacy,lung function,and improvement of clinical symptoms were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.00%,which was higher than 80.00% in the control group.The difference was statistically significant (P < 0.05).Before treatment,there was no significant difference in the forced vital capacity (FVC) and the percentage of forced expiratory volume in the first second (FEV1%) between the two groups of patients (P > 0.05);after treatment,the FVC and FEV1% of the two groups of patients were higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant (P < 0.05).The disappearance times of fever,cough,and chest tightness in the observation group were shorter than those in the control group,the differences were statistically significant (P < 0.05).Conclusion Xiyanping injection combined with piperacillin and sulbactam is effective in the treatment of CAP,which can shorten the remission time of clinical symptoms and improve lung function.