丁苯酞联合补阳还五汤对脑梗死的疗效

Efficacy of Butylphthalide Combined with Buyang Huanwu Decoction on Cerebral Infarction

目的:观察丁苯酞联合补阳还五汤对脑梗死的疗效。方法:选取郑州人民医院2017年8月至2019年8月期间收治的140例脑梗死患者,按照双色球随机分配原则将患者分为对照组(70例:丁苯酞治疗)与观察组(70例:丁苯酞联合补阳还五汤治疗),比较两组患者预后效果。结果:治疗前两组患者的肿瘤坏死因子–α(TNF–α)、白细胞介素–6(IL–6)、超敏C反应蛋白(hs–CRP)比较,差异无统计学意义(P>0.05);治疗后观察组患者的TNF–α、IL–6、hs–CRP均低于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者的D–二聚体(D–D)、纤维蛋白原(FIB)比较,差异无统计学意义(P>0.05);治疗后观察组患者的D–D、FIB均低于对照组,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率为97.15 %,高于对照组的87.14 %,差异具有统计学意义(P<0.05)。结论:脑梗死患者丁苯酞联合补阳还五汤治疗效果明显优于单一丁苯酞治疗。

Objective To observe the effect of butylphthalide combined with Buyang Huanwu Decoction on cerebral infarction.Methods A total of 140 patients with cerebral infarction admitted to Zhengzhou People’s Hospital from August 2017 to August 2019 were selected,Patients were divided into a control group (70 cases:butylphthalide treatment) and an observation group (70 cases:butylphthalide combined with Buyang Huanwu Decoction treatment) according to the principle of random allocation of two-color balls,and the prognostic effects of the two groups were compared.Results Before treatment,there was no statistically significant difference in tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),and hypersensitive C-reactive protein (hs-CRP) between the two groups (P > 0.05).After treatment,the levels of TNF-α,IL-6 and hs-CRP of the observation group were lower than those of the control group,and the difference was statistically significant (P < 0.05).Before treatment,there was no significant difference in coagulation factor D-dimer (D-D) and fibrinogen (FIB) between the two groups (P > 0.05).After treatment,the levels of D-D and FIB of the observation group were lower than those of the control group,and the difference was statistically significant (P < 0.05).the total effective rate of treatment for patients in the observation group was 97.15% higher than 87.14% in the control group,and the difference was statistically significant(P < 0.05).Conclusion The therapeutic effect of butylphthalide combined with Buyang Huanwu Decoction in patients with cerebral infarction is significantly better than that of single butylphthalide.