嗜酸粒细胞(Eos)与慢性鼻窦炎伴鼻息肉患者的临床病理特征的关系研究

Relationship between eosinophils(Eos)and clinicopathological features of patients with chronic sinusitis and nasal polyps

目的探索嗜酸粒细胞(Eos)与慢性鼻窦炎伴鼻息肉患者的临床病理特征的关系。方法回顾性分析2017年1月至2019年1月于深圳市中西医结合医院接受治疗的122例慢性鼻窦炎伴鼻息肉患者的临床资料,根据病理切片是否发生Eos浸润将患者分为试验组和对照组,试验组发生Eos浸润,对照组未发生Eos浸润。收集患者临床资料并对比临床特征,采用Lund-Kennedey以及Lund-Mackey评估标准对患者鼻窦病变范围及程度进行评价。结果试验组Eos百分比显著高于对照组Eos百分比,数据对比具有统计学差异(P<0.05)。试验组鼻漏Lund-Kennedey评分显著高于对照组,数据对比具有统计学差异(P<0.05)。试验组上颌窦Lund-Mackey评分显著高于对照组,试验组后组筛窦、鼻道窦口复合体、蝶筛隐窝Lund-Mackey评分明显高于对照组,数据对比具有统计学差异(P<0.05)。多因素回归分析结果显示,鼻漏、上颌窦、鼻道窦口复合体、蝶筛隐窝病变是导致慢性鼻窦炎伴鼻息肉患者发病的独立危险因素(P<0.05)。结论Eos慢性鼻窦炎伴鼻息肉患者与Non-Eos慢性鼻窦炎伴鼻息肉患者临床特征存在较大差异,术前内镜检查、CT检查结果有助于患者进行慢性鼻窦炎伴鼻息肉分型。

Objective To explore the relationship between eosinophils(Eos)and the clinicopathological features of patients with chronic sinusitis and nasal polyps.Methods A clinical data of 122patients with chronic sinusitis and nasal polyps treated in Shenzhen hospital of integrated traditional chinese and western medicine hospital from January 2017to January 2019were retrospectively analyzed.According to whether Eos infiltration occurred in pathological sections,patients were divided into observation group and control group.Observation group Eos infiltration occurred and Eos infiltration did not occur in the control group.Clinical data were collected and clinical characteristics were compared.Lund-Kennedey and Lund-Mackey evaluation criteria were used to evaluate the extent and extent of sinus lesions.Results The percentage of Eos in the observation group was significantly higher than that in the control group,and the data were statistically different(P<0.05).The Lund-Kennedey score of the observation group was significantly higher than that of the control group,and the data were statistically significant(P<0.05).The Lund-Mackey score of the maxillary sinus in the observation group was significantly higher than that in the control group.The Lund-Mackey score of the ethmoid sinus,nasal sinus ostium complex and butterfly sac was significantly higher in the observation group than in the control group(P<0.05).Multivariate regression analysis showed that nasal leakage,maxillary sinus,nasal sinus ostium complex,and stencil crypt lesion were independent risk factors for chronic sinusitis with nasal polyps(P<0.05).Conclusion The clinical features of patients with chronic sinusitis with nasal polyps and Non-Eos chronic sinusitis with nasal polyps are quite different.Preoperative endoscopy and CT findings are helpful for patients with chronic sinusitis with nasal polyps.