基于数据挖掘的朱仁康治疗湿疹的内服方药规律研究

Research on the regularity of Zhu Renkang’s oral prescriptions in the treatment of eczema based on data mining

目的分析朱仁康治疗湿疹的方剂规律,明晰隐藏的处方用药经验与学术思想,以期指导湿疹临床治疗并提高临床疗效。方法以朱仁康教授门诊病历、文献医案为数据源,运用中国中医科学院中医药信息研究所研发的古今医案云平台V1.4软件,采用频数分析、关联规则分析方法进行数据挖掘,确定处方中核心药物组合、用药模式及药物间的关联规则等。结果本研究共纳入湿疹患者168例,190诊次,临床表现主要包括瘙痒、渗出、丘疹、水疱、干燥、皮损色红等;方剂主要包括湿一号、牛黄清热散、防风通圣丸、二妙丸、神二方。四诊信息与方剂的关联规则总结出症状与方剂的对应关系,核心药物组合的复杂网络分析出湿疹一号方及两个新方剂。朱仁康治疗湿疹常用方有湿一号(龙胆泻肝汤化裁)、牛黄清热散、防风通圣丸、二妙丸、神二方、小败毒膏、湿四号。结论朱仁康治疗湿疹主方以龙胆泻肝汤化裁,治疗湿疹从湿、从火、从风遣方用药,达到整体调节、改善症状及减少复发的目的。

Objective To explore professor Zhu Renkang’s prescription regularities in curing eczema, and to clarify the implied experience and academic thought in order to guide the clinical treatment of eczema and improve the clinical efficacy.Methods Professor Zhu Renkang’s outpatient medical records and literature medical records were used as data resource. The software ancient and modern medical case cloud platform V1.4 developed by Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences was used to conduct data mining. Frequency analysis and association rules analysis methods were used to explore the core combinations, combination patterns and rules of combination patterns. Results A total of 168 cases eczema patients were included in this study, with 190 times of diagnosis and treatment. The common clinical symptoms of eczema mainly included pruritus, exudation, papules, blisters, dryness, red skin lesions, etc;commonly used prescriptions were Shiyifang, Niuhuang Qingre Powder, Fangfeng Tongsheng Pill, Ermiao Pill, Shenerfang. The association rules between the four diagnostic information and prescriptions summarized the corresponding relationship between symptoms and prescriptions, and the complex network of core drug combination analyzed the Shiyifang and two new prescriptions. Zhu Renkang commonly used in the treatment of eczema were Shiyifang(modified Longdan Xiegan Decoction), Niuhuang Qingre Powder, Fangfeng Tongsheng Pill, Ermiao Pill, Shenerfang, Xiaobaidugao, Shisifang. Conclusion Zhu Renkang’s main prescription for the treatment of eczema is modified Longdan Xiegan Decoction, and the treatment of eczema is from wet, from fire, from wind, so as to achieve the purpose of overall regulation, improvement of symptoms and reduction of recurrence.