阻塞性睡眠呼吸暂停合并肺癌的研究进展

Research progress of obstructive sleep apnea complicated with lung cancer

阻塞性睡眠呼吸暂停(OSA)是患者在夜间睡眠时形成周期性缺氧-复氧循环,即间歇性缺氧。肺癌是最常见的恶性肿瘤,预后差。近年来,越来越多的研究探讨了OSA对肺癌的影响,提示OSA可增强肺癌细胞的增殖、侵袭及迁移能力。这可能与OSA造成的间歇性缺氧诱导缺氧诱导因子-1α(HIF-1α)增加及肺癌细胞中程序性死亡配体1(PD-L1)表达增强有关。该文综述了OSA与肺癌的关系及影响肺癌的可能机制,总结了模拟OSA样间歇性缺氧合并肺癌的细胞及动物模型。

Obstructive sleep apnea(OSA)is a disorder characterized by a periodic hypoxia-reoxygenation cycle during nighttime sleep,that is,intermittent hypoxia.Lung cancer is the most common malignant tumor with poor prognosis.In recent years,more and more studies have explored the effect of OSA on lung cancer,suggesting that OSA can enhance the proliferation,invasion and migration of lung cancer cells.This may be related to the increase of intermittent hypoxia-induced hypoxia-inducible factor-1α(HIF-1α)caused by OSA and the enhanced expression of programmed death-ligand 1(PD-L1)in lung cancer cells.This paper reviews the relationship between OSA and lung cancer and the potential mechanisms that affect lung cancer,and summarizes the cell and animal models simulating OSA-like intermittent hypoxia complicated with lung cancer.