基于多糖的高吸水率可吸收止血材料的研究

Absorbable Hemostatic Material with High Water Absorption Based on Polysaccharide

制备了一种基于多糖的可吸收止血材料,通过减少血液中的水分提升血细胞及凝血因子的浓度,从而降低凝血时间,达到快速止血的目的。通过使用盐酸酸解马铃薯淀粉增加淀粉的比表面积,使其能更容易与α-淀粉酶结合,增加降解速率。使用交联剂将淀粉交联成微球,使其粒径均一,且能大大提升吸水率。通过对交联淀粉微球表面改性羧甲基,能进一步提高止血材料的吸水率。结果表明,该研究中的止血材料,吸水率可达800%以上,动物模型中平均止血时间为138.7 s,与市面上销售的进口产品相比,该研究的止血材料止血性能更优。

An absorbable hemostatic material based on polysaccharide was prepared.The concentration of blood cells and coagulation factors was increased by reducing the water content in the blood,so as to reduce the coagulation time and achieve the purpose of rapid hemostasis.The specific surface area of starch was increased by using hydrochloric acid to hydrolyze potato starch,which made it easier to combine withα-amylase and increased the degradation rate.Starch was crosslinked into microspheres by crosslinking agent,which made the particle size uniform and greatly improved the water absorption.The surface modification of crosslinked starch microspheres with carboxymethyl group can further improve the water absorption of hemostatic materials.The results showed that the water absorption rate of our hemostatic material was more than 800%,and the average hemostatic time in the animal model was 138.7 s.Compared with the imported products on the market,our hemostatic material have better hemostatic performance.