促智颗粒治疗血管性痴呆临床观察及对血清Hcy水平的影响

Clinical efficacy observation of Cuzhi granule on vascular dementia and its effect on level of serum Hcy

目的:观察促智颗粒治疗血管性痴呆的临床疗效及对血清同型半胱氨酸(Hcy)水平的影响。方法:按随机数字表法将76例血管性痴呆患者分为两组各38例,两组均予西医基础治疗,对照组另予盐酸多奈哌齐片,治疗组在对照组的基础上加用促智颗粒,两组疗程均为60天。观察两组临床疗效及治疗前后简易精神状态检查量表(MMSE)评分、日常生活能力量表(ADL)评分、血清Hcy水平。结果:治疗组总有效率为92.11%,高于对照组的76.32%(P﹤0.05);治疗后两组MMSE评分及ADL评分均较治疗前升高(P﹤0.05),血清Hcy水平均较治疗前下降(P﹤0.05),且治疗组各指标均优于对照组(P﹤0.05)。结论:促智颗粒治疗血管性痴呆临床疗效显著,能够降低患者血清Hcy水平,提高日常生活能力,改善认知功能。

Objective:To observe the clinical efficacy of Cuzhi granule on vascular dementia and its effect on level of serum homocysteine(Hcy).Methods:76 cases of patients with vascular dementia were randomly divided into two group by random number table,38 cases in each group.Both groups were treated with basic western medicine.The control group was treated plus with donepezil hydrochloride tablets,while the treatment group was treated plus with Cuzhi granule on the basis of control group.The course of treatment was 60 days for both groups.The clinical efficacy,mini-mental state examination scale(MMSE),activities of daily life scale(ADL score)and level of serum Hcy were observed in two groups before and after treatment.Results:The total effective rate of treatment group was 92.11%,which was higher than 76.32%of control group(P﹤0.05).After treatment in two groups,MMSE score and ADL score were higher than before treatment(P﹤0.05);the level of serum Hcy was lower than before treatment(P﹤0.05);and the various indexes of treatment group were better than those of control group(P﹤0.05).Conclusion:The clinical efficacy of Cuzhi granule on vascular dementia is significant,which can reduce the level of serum Hcy of patients,improve the ability of daily living and enhance the cognitive function.