社区非小细胞肺癌患者生存现状及危险因素分析

Analysis of survival status and risk factors of patients with non-small cell lung cancer in the community

目的:对上海市静安区彭浦新村街道非小细胞肺癌患者的发病情况及生存率进行统计分析,为非小细胞肺癌患者的管理及综合防治提供依据。方法:选取于1989年6月1日—2018年12月31日期间确诊的上海市静安区彭浦新村街道非小细胞肺癌患者,通过“上海市恶性肿瘤新发病例报告卡”和疾病控制信息管理平台收集333例非小细胞肺癌患者的相关病例资料。结果:Kaplan-Meier单因素分析结果显示,性别、年龄、病理学类型、TNM分期和是否经过手术治疗是非小细胞肺癌患者生存时间的影响因素(P<0.05),将单因素分析中有统计学意义的影响因素进一步纳入COX回归模型进行多因素分析,结果显示性别、TNM分期和是否经过手术治疗是影响非小细胞肺癌患者生存结局的独立因素。结论:探索影响非小细胞肺癌患者生存率的相关危险因素对预防本病的发生发展及治疗具有重要意义。希望通过一系列相关研究建立非小细胞肺癌的分级联动疾病管理模式,对高危人群进行健康干预、健康管理和筛查预警,对非小细胞肺癌患者做到早发现、早治疗、有效随访和精细管理,有效延长患者的生存时间。

Objective:To statistically analyze the incidence and survival rate of non-small cell lung cancer patients in Pengpuxincun Community of Jingan District,Shanghai and to provide basis for management and comprehensive prevention and treatment for non-small cell lung cancer patients.Methods:Patients with non-small cell lung cancer diagnosed in Pengpuxincun Community of Jingan District,Shanghai from June 1,1989 to December 31,2018 were selected,and the relevant case data of 333 patients with non-small cell lung cancer were collected through the“Shanghai new malignant tumor case report card”and the disease control information management platform.Results:Kaplan-Meier univariate analysis showed that gender,age,pathological type,TNM stage and whether having surgical treatment were the influencing factors of survival time of patients with non-small cell lung cancer(P<0.05),the statistically significant influencing factors in univariate analysis were further incorporated into Cox regression model for multivariate analysis,and the results showed that gender,TNM stage and whether having surgical treatment were independent factors affecting the survival outcome of patients with non-small cell lung cancer.Conclusion:To explore the related risk factors that affect the survival rate of patients with non-small cell lung cancer is of great significance to the prevention of the development and treatment of this disease.It is hoped that through a series of related studies,a hierarchical and linked disease management mode for non-small cell lung cancer will be established to carry out health intervention,health management,screening and early warning for high-risk groups,and achieve early detection,early treatment,effective follow-up and fine management for patients with non-small cell lung cancer,so as to effectively prolong the survival time of patients.