黄芩汤联合序贯肝动脉化疗栓塞术对原发性肝癌患者血清NF-κB、HIF-1α、AFP水平和肝功能的影响

Effects of Huangqin Decoction combined with sequential hepatic arterial chemoembolization on the serum levels of NF-κB,HIF-1α and AFP and the liver function in patients with primary hepatic carcinoma

目的探讨黄芩汤联合序贯肝动脉化疗栓塞术对原发性肝癌患者血清NF-κB、HIF-1α、AFP水平和肝功能的影响。方法选取120例原发性肝癌患者,按随机数表法分为观察组与对照组,各60例。对照组予序贯肝动脉化疗栓塞术,观察组在对照组基础上加用黄芩汤,2组均治疗8周。比较2组治疗前后中医证候积分、肝功能指标及血清细胞因子水平;统计2组治疗期间不良反应发生情况。结果与治疗前比较,治疗后2组中医证候积分及血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)水平、核因子-κB(NF-κB)、缺氧诱导因子-1α(HIF-1α)、甲胎蛋白(AFP)水平均降低,且观察组均低于对照组(P<0.05)。观察组治疗期间不良反应发生率与对照组比较差异不显著(P>0.05)。结论黄芩汤联合序贯肝动脉化疗栓塞术可改善原发性肝癌患者中医证候及肝功能,降低患者血清NF-κB、HIF-1α、AFP水平,缓解炎症。

Objective To investigate the effects of Huangqin Decoction combined with sequential hepatic arterial chemoembolization on the serum levels of NF-κB,HIF-1αand AFP and the liver function in patients with primary hepatic carcinoma.Methods A total of 120 patients with primary hepatic carcinoma were randomly divided into an observation group and a control group,with 60 cases in each group.The control group was treated with sequential hepatic arterial chemoembolization,while the observation group was additionally treated with Huangqin Decoction,both for 8 weeks.The TCM syndrome score,liver function index and serum cytokine level were compared between the two groups before and after treatment.The adverse reactions in the 2 groups during treatment were counted.Results Compared with before treatment,the TCM syndrome scores,serum levels of aspartate aminotransferase (AST),alanine aminotransferase (ALT),total bilirubin (TBIL),nuclear factor-κB (NF-κB),hypoxia-inducible factor-1α (HIF-1α) and alpha-fetoprotein (AFP) in the 2 groups were decreased after treatment,and the observation group was lower than the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).Conclusion Huangqin Decoction combined with sequential hepatic arterial chemoembolization can improve the TCM syndrome and liver function,reduce the levels of NF-κB,HIF-1α and AFP and relieve inflammation in patients with primary hepatic carcinoma.