甲胎蛋白水平与中晚期原发性肝癌TACE术后疗效和预后的相关性分析

Analysis of correlation between alpha-fetoprotein level and curative effect and prognosis of advanced primary liver cancer after TACE

目的探讨中晚期原发性肝癌患者术前血清甲胎蛋白表达水平与经导管肝动脉化疗栓塞术(TACE)术后疗效和预后的相关性。方法回顾性分析2012年1月至2017年4月绍兴第二医院收治的114例TACE治疗的中晚期原发性肝癌患者的临床资料,比较36例AFP阴性患者和78例AFP阳性患者的治疗效果和生存情况。结果 AFP阴性组第6、12个月的疾病控制率高于AFP阳性组(P<0.05),第36、48个月生存率高于AFP阳性组(P<0.05)。AFP≤400 ng/mL组与AFP>400 ng/mL组患者治疗后疾病控制率和生存率比较,差异均无统计学意义(P>0.05)。结论甲胎蛋白水平与中晚期原发性肝癌TACE术后疗效有一定的相关性,TACE对AFP阴性的患者有更好的疗效和预后。

Objective To explore the correlation between expression level of serum alpha-fetoprotein before operation and curative effect and prognosis of patients with advanced primary liver cancer after TACE. Methods The clinical data of 114 patients with advanced primary liver cancer treated by TACE from January 2012 to Aprial 2017 in Shaoxing Second Hospital were analyzed retrospectively,and the therapeutic effects and survival conditions of 36 patients with negative AFP and 78 patients with positive AFP were compared. Results The disease control rate of AFP-negative group in the 6 th and 12 th month was higher than that in the AFP-positive group(P<0.05), and the survival rate in the36 th and 48 th month was higher than that in the AFP-positive group(P<0.05).There were no significant differences in the disease control rate and survival rate between AFP≤400 ng/mL group and AFP>400 ng/mL group after treatment(P>0.05). Conclusion The level of alpha-fetoprotein is related to the curative effect of TACE for advanced primary liver cancer, and TACE has better curative effect and prognosis for AFP negative patients.