氯沙坦钾氢氯噻嗪片治疗老年原发性高血压的临床效果观察

Clinical efficacy of losartan potassium and hydrochlorothiazide tablets in the treatment of essential hypertension in the elderly

目的分析老年原发性高血压患者应用氯沙坦钾氢氯噻嗪片治疗的效果。方法 96例老年原发性高血压患者,随机分为对照组和观察组,每组48例。对照组采用氢氯噻嗪片治疗,观察组采用氯沙坦钾氢氯噻嗪片治疗。比较两组患者治疗效果及治疗前后血压水平。结果观察组患者的治疗总有效率97.92%高于对照组的85.42%,差异具有统计学意义(P<0.05)。治疗前,两组患者的清晨收缩压(SBP)、舒张压(DBP)及24 h动态SBP、DBP水平比较差异无统计学意义(P>0.05);治疗后,两组患者的清晨SBP、DBP及24 h动态SBP、DBP水平均较治疗前降低,且观察组患者的清晨SBP(135.14±7.04)mm Hg(1 mm Hg=0.133 kPa)、DBP(86.53±6.78)mm Hg及24 h动态SBP(134.24±9.61)mm Hg、DBP(84.81±8.80)mm Hg低于对照组的(140.26±8.17)、(92.06±7.36)、(142.36±9.16)、(89.03±8.05)mm Hg,差异具有统计学意义(P<0.05)。结论老年原发性高血压患者应用氯沙坦钾氢氯噻嗪片治疗的效果比较好,可以明显改善血压水平,具有较高的应用价值。

Objective To analyze the therapeutic effect of losartan potassium and hydrochlorothiazide tablets in the treatment of essential hypertension in the elderly. Methods A total of 96 elderly patients with essential hypertension were randomly divided into control group and observation group, with 48 cases in each group. The control group was treated with hydrochlorothiazide tablets, and the observation group was treated with losartan potassium and hydrochlorothiazide tablets. The therapeutic effects and blood pressure levels before and after treatment were compared between the two groups. Results The total effective rate 97.92% of the observation group was higher than 85.42% of the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in morning systolic blood pressure(SBP), diastolic blood pressure(DBP) and 24 h dynamic SBP and DBP levels between the two groups(P>0.05). After treatment,the morning SBP, DBP and 24 h dynamic SBP and DBP levels of the two groups were lower than those of this group before treatment;the morning SBP(135.14±7.04) mm Hg(1 mm Hg=0.133 kPa), morning DBP(86.53±6.78) mm Hg, 24 h dynamic SBP(134.24±9.61) mm Hg, and 24 h dynamic DBP(84.81±8.80) mm Hg of the observation group were lower than(140.26±8.17),(92.06±7.36),(142.36±9.16), and(89.03±8.05) mm Hg of the control group;all the differences were statistically significant(P<0.05). Conclusion Losartan potassium and hydrochlorothiazide tablets have achieved good therapeutic effect in the treatment of elderly patients with essential hypertension, which can significantly improve the blood pressure level and has high application value.