阿托伐他汀与辛伐他汀治疗高脂血症的效果对比

Comparison of effects of atorvastatin and simvastatin in the treatment of hyperlipidemia

目的对比阿托伐他汀与辛伐他汀治疗高脂血症的效果。方法 96例高脂血症患者,随机分为观察组与对照组,每组48例。对照组使用辛伐他汀治疗,观察组使用阿托伐他汀治疗。比较两组患者的临床治疗效果,治疗前后的血脂指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,不良反应发生情况。结果观察组患者的治疗总有效率95.83%高于对照组的81.25%,差异具有统计学意义(P<0.05)。治疗后,两组患者的TC、TG、LDL-C水平低于本组治疗前, HDL-C水平高于本组治疗前,且观察组患者的TC(2.40±0.52)mmol/L、TG(1.15±0.18)mmol/L、LDL-C(2.58±0.25)mmol/L低于对照组的(3.26±0.41)、(1.45±0.17)、(3.24±0.37)mmol/L,HDL-C(1.14±0.12)mmol/L高于对照组的(1.08±0.13)mmol/L,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率4.17%低于对照组的16.67%,差异具有统计学意义(P<0.05)。结论阿托伐他汀治疗高脂血症的效果优于辛伐他汀,可以改善相关血脂指标,用药后的不良反应较少,安全性较高,可以推广。

Objective To compare the effects of atorvastatin and simvastatin in the treatment of hyperlipidemia. Methods A total of 96 patients with hyperlipidemia were randomly divided into observation group and control group, with 48 cases in each group. The control group was treated with simvastatin, and the observation group was treated with atorvastatin. Both groups were compared in terms of therapeutic effect, blood lipid indexes [total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C)] before and after treatment, and occurrence of adverse reactions. Results The total effective rate of treatment 95.83% in the observation group was higher than 81.25% of the control group,and the difference was statistically significant(P<0.05). After treatment, the TC, TG, and LDL-C of the two groups were lower than those of this group before treatment, and the HDL-C washigher than that of this group before treatment;the TC(2.40±0.52) mmol/L, TG(1.15±0.18) mmol/L, LDL-C(2.58±0.25) mmol/L of the observation group were lower than(3.26±0.41),(1.45±0.17),(3.24±0.37) mmol/L of the control group, and the HDL-C(1.14±0.12) mmol/L was higher than(1.08±0.13) mmol/L of the control group. All the differences were statistically significant(P<0.05). The incidence of adverse reactions 4.17% in the observation group was lower than 16.67% in the control group, and the difference was statistically significant(P<0.05). Conclusion Compared with simvastatin, atorvastatin has a higher therapeutic effect in the treatment of hyperlipidemia, and can improve the relevant blood lipid indicators with fewer adverse reactions and higher safety, which can be promoted.