甲巯咪唑片和丙硫氧嘧啶片治疗甲亢患者的临床疗效及安全性分析

Analysis of the clinical efficacy and safety of thiamazole tablets and propylthiouracil tablets in the treatment of hyperthyroidism

目的探析针对甲状腺功能亢进症(甲亢)患者采用甲巯咪唑片和丙硫氧嘧啶片治后的临床效果及安全性。方法 84例甲状腺功能亢进症患者,根据住院顺序按照单双号分为常规组和实验组,每组42例。常规组采用丙硫氧嘧啶片治疗,实验组采用甲巯咪唑片治疗。比较两组临床疗效、不良反应发生率以及治疗前后的甲状腺功能指标[血清游离甲状腺素(FT_(4))、血清游离三碘甲状腺原氨酸(FT_(3))及促甲状腺激素(TSH)]水平。结果实验组治疗总有效率为95.24%(40/42),其中显效15例,有效25例,无效2例;常规组治疗后总有效率为80.95%(34/40),其中显效12例,有效22例,无效8例。实验组治疗总有效率高于常规组,差异无统计学意义(χ^(2)=4.086, P=0.043<0.05)。治疗后,实验组患者治疗后的FT_(4)(12.13±0.96)pmol/L、FT_(3)(3.66±0.86)pmol/L、TSH(1.95±0.70)mU/ml均优于常规组的(13.05±0.88)pmol/L、(4.35±1.56)pmol/L、(1.32±0.62)mU/ml,差异均具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论甲巯咪唑片和丙硫氧嘧啶片治疗甲状腺功能亢进患者,前者的疗效较为显著,具有一定的临床应用价值。

Objective To discuss and analyze the clinical efficacy and safety of thiamazole tablets and propylthiouracil tablets in the treatment of hyperthyroidism. Methods A total of 84 patients with hyperthyroidism were divided into the conventional group and the experimental group according to the hospitalization order, with 42 cases in each group. The conventional group was treated with propylthiouracil tablets, and the experimental group was treated with thiamazole tablets. Both groups were compared in terms of clinical efficacy, incidence of adverse reactions, and thyroid function indexes [serum free thyroxine(FT_(4)), serum free triiodothyronine(FT_(3)) and thyroid stimulating hormone(TSH)] before and after treatment. Results The total effective rate of treatment in the experimental group was 95.24%(40/42), of which 15 cases were markedly effective, 25 cases were effective,and 2 cases were ineffective;the total effective rate after treatment in the conventional group was 80.95%(34/40),of which 12 cases were markedly effective, 22 cases were effective, and 8 cases were ineffective. The total effective rate of treatment in the experimental group was higher than that in the conventional group, and the difference was statistically significant(χ^(2)=4.086, P=0.043<0.05). After treatment, the FT_(4)(12.13±0.96) pmol/L, FT_(3)(3.66±0.86) pmol/L, and TSH(1.95±0.70) mU/ml of the experimental group were better than(13.05±0.88) pmol/L,(4.35±1.56) pmol/L, and(1.32±0.62) mU/ml of the conventional group, and the differences were statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion In the treatment of hyperthyroidism patients with thiamazole tablets and propylthiouracil tablets, the former is more effective and has certain clinical application value.