植物多酚通过RAGE/MAPK/NF-κB通路抑制AGEs诱导的炎症反应研究进展

Plant Polyphenols Inhibit AGEs-Induced Inflammatory Responses through the RAGE/MAPK/NF-κB Signaling Pathway:A Review

晚期糖基化终末产物(advanced glycation end products,AGEs)是在美拉德反应末期,蛋白质、氨基酸、脂类或核酸等的游离氨基与还原糖(葡萄糖、果糖、戊糖等)的羰基进行反应后产生的一类稳定产物。AGEs可以与AGE受体(receptor for advanced glycation end product,RAGE)相互作用,启动其下游的相关信号通路从而诱导氧化应激和炎症反应。植物多酚能抑制AGEs诱导的RAGE上调,抑制核转录因子(nuclear factor kappa B,NF-κB)磷酸化和丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)的活化,并显著降低炎症介质的基因表达,包括肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和IL-6等。基于此,本文全面综述了植物多酚通过RAGE/MAPK/NF-κB信号通路调节AGEs诱导的炎症因子基因表达的作用机制,以期为研发植物多酚类抗氧化和抗炎保健食品或药品提供一定的科学依据。

Advanced glycation end products(AGEs)are stable end products produced by the reaction of free amino groups in proteins,amino acids,lipids or nucleic acids with carboxyl groups in reduced sugars(glucose,fructose and sugar)toward the end of the Maillard reaction.AGEs can interact with the receptor for advanced glycation end products(RAGEs)to activate certain downstream signaling pathways and consequently induce oxidative stress and inflammation.Plant polyphenols can inhibit AGEs-induced RAGE up-regulation,suppress the phosphorylation of nuclear factor kappa B(NF-κB)and the activation of mitogen-activated protein kinases(MAPKs),and significantly down-regulate the gene expression of inflammatory mediators including tumor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β)and interleukin-6(IL-6).Therefore,this paper summarizes the mechanism of action by which plant polyphenols regulate AGEs-induced gene expression of inflammatory factors through the RAGE/MAPK/NF-κB signaling pathway.We expect this review to provide a scientific basis for the development of antioxidant and anti-inflammatory nutraceuticals and pharmaceuticals based on plant polyphenols.