半剂量生长抑素辅助奥曲肽治疗急性胰腺炎患者的疗效及对其炎症因子水平的影响

Efficacy of half-dose somatostatin combined with octreotide in the treatment of patients with acute pancreatitis and its influence on the levels of inflammatory factors

目的分析在急性胰腺炎的治疗中,半剂量生长抑素辅助奥曲肽的临床效果。方法90例急性胰腺炎患者,采用计算机生成的随机数字表将所有患者分为常规组和联合组,每组45例。常规组采用奥曲肽治疗,联合组采用半剂量生长抑素联合奥曲肽治疗。比较两组患者治疗前后炎症因子、铁蛋白、细胞间粘附分子-1水平以及治疗效果、不良反应发生率。结果治疗后,联合组患者超敏C反应蛋白(12.58±1.81)mg/L、肿瘤坏死因子-α(33.95±4.81)ng/L、血清白细胞介素-6(10.11±1.25)ng/L均低于常规组的(19.75±2.85)mg/L、(41.92±5.89)ng/L、(14.26±1.52)ng/L,差异均具有统计学意义(P<0.05)。治疗后,联合组治疗总有效率95.6%高于常规组的80.0%,差异具有统计学意义(P<0.05)。治疗后,联合组患者铁蛋白(524.18±76.92)ng/ml及细胞间粘附分子-1(6.04±0.78)ng/ml均低于常规组的(586.41±80.77)、(7.25±0.84)ng/ml,差异均具有统计学意义(P<0.05)。联合组不良反应发生率13.3%低于常规组的40.0%,差异具有统计学意义(P<0.05)。结论半剂量生长抑素辅助奥曲肽治疗能够降低急性胰腺炎患者炎症因子水平,提高疗效,降低铁蛋白及细胞间粘附分子-1水平以及不良反应发生率。

Objective To analyze the clinical effect of half-dose somatostatin combined with octreotide in the treatment of patients with acute pancreatitis and its influence on the levels of inflammatory factors.Methods A total of 90 patients with acute pancreatitis were divided into conventional group and combination group according to computer-generated random numerical table,with 45 cases in each group.The conventional group was treated with octreotide,and the combination group was treated with half-dose somatostatin and octreotide.Both groups were compared in terms of levels of inflammatory factors,ferritin and intercellular adhesion molecule-1 before and after treatment,therapeutic effects,and incidence of adverse reactions.Results After treatment,the high-sensitivity C-reactive protein(12.58±1.81)mg/L,tumor necrosis factor-α(33.95±4.81)ng/L,and serum interleukin-6(10.11±1.25)ng/L of the combination group were lower than(19.75±2.85)mg/L,(41.92±5.89)ng/L,and(14.26±1.52)ng/L of the conventional group,and the differences were statistically significant(P<0.05).After treatment,the total effective rate of treatment 95.6%in the combination group was higher than 80.0%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the ferritin(524.18±76.92)ng/ml and intercellular adhesion molecule-1(6.04±0.78)ng/ml in the combination group were lower than(586.41±80.77)and(7.25±0.84)ng/ml in the conventional group,and the difference was statistically significant(P<0.05).The incidence of adverse reaction 13.3%in the combination group was lower than 40.0%in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Half-dose somatostatin combined with octreotide can reduce the levels of inflammatory factors,improve the efficacy,reduce the levels of ferritin and intercellular adhesion molecule-1,and lower the incidence of adverse reactions in patients with acute pancreatitis.