氨甲环酸氯化钠注射液致心慌和肌肉震颤1例及文献分析

One Case of Palpitation and Muscle Tremor Induced by Tranexamicacid Acid Sodiwn Chloride Injection and Literature Analysis

目的探讨氨甲环酸氯化钠注射液致心慌、肌肉震颤的原因及处置措施。方法分析1例氨甲环酸氯化钠致心慌、肌肉震颤的诊疗经过,结合文献检索,探索氨甲环酸氯化钠导致心慌、肌肉震颤的机制及应对措施。结果患者使用氨甲环酸氯化钠突发心慌、肌肉震颤,可能与滴注速度过快有关,注意给药剂量、速度、浓度可减少药品不良反应的发生;也可能是氨甲环酸诱发癫痫的前兆,早期脑电图监测有助于诊断,一些全身麻醉药物和苯二氮类药物可用于治疗;还可能是氨甲环酸诱发的Ⅰ型药物过敏反应,应及时给予抗过敏处理。结论临床在使用氨甲环酸过程中应加强观察,如发生不良反应,应立即停药,针对不同情况,采取相应急救措施。

Objective To explore the causes of palpitation and muscle tremor induced by tranexamic acid sodium chloride injection and the treatment measures.Methods The diagnosis and treatment of a case of palpitation and muscle tremor induced by tranexamic acid sodium chloride were analyzed.Combined with literature search,the mechanism and countermeasures of panic and tremor induced by tranexamic acid sodium chloride were explored.Results Sudden palpitation and muscle tremor in patients with tranexamic acid sodium chloride may be related to excessive infusion rate,pay attention to the dose,speed,concentration can reduce the occurrence of adverse drug reactions,may also be a precursor to tranexamic acid-induced epilepsy,early EEG monitoring is helpful for diagnosis,some general anesthesia drugs and benzodiazepines may be used for treatment;or may be tranexamic acid-induced typeⅠdrug allergy reaction,and anti-allergic treatment should be given in time.Conclusion In the course of clinical use of tranexamic acid,it is necessary to strengthen observation.In case of adverse reactions,the drug should be stopped immediately,and corresponding emergency measures should be taken according to different situations.