在ICSI时应用SperMagic对无精子症患者辅助生殖结局的影响

Effects of SperMagic Application in ICSI on Assisted Reproductive Outcomes in Azoospermia Patients

目的:探究在卵胞浆内单精子显微注射(ICSI)时应用SperMagic对无精子症患者的临床效果。方法:选取2019年1月至2021年1月佛山市妇幼保健院收治的200例移植周期的无精子症患者,遵循随机数字表法将纳入对象随机分为观察组及对照组,各100例。其中对照组患者精子处理后行ICSI,观察组患者在精子处理后添加精子激动剂SperMagic。比较两组患者精子活力以及辅助生殖结局等相关指标差异。结果:精子在经相应处理后,观察组患者的精子活力为(92.6±3.6)%,与对照组精子活力(67.6±11.4)%相比,差异具有统计学意义(P<0.05)。与对照组相比,观察组患者的受精率、优胚率、种植率、妊娠率及流产率等辅助生殖结局指标显著更优,差异具有统计学意义(P<0.05)。结论:在ICSI时加入精子激动剂SperMagic,可显著提高精子活力,改善妊娠结局。

Objective To explore the clinical effect of SperMagic on azoospermia patients during intracytoplasmic sperm microinjection(ICSI).Methods From January 2019 to January 2021,200 patients with azoospermia in the transplantation cycle admitted to the Foshan Maternal and Child Health Hospital were selected,and the subjects were randomly divided into observation group and control group,with 100 cases in each group,following the random number table method.The control group received ICSI after sperm processing,and the observation group received the sperm agonist SperMagic after sperm processing.The differences in sperm motility and assisted reproduction outcomes between the two groups of patients were compared.Results After corresponding treatment of sperm,the sperm motility of the observation group was(92.6±3.6)%,which was statistically significant(P<0.05)compared with the sperm motility of the control group(67.6±11.4)%.Compared with the control group,the observation group had significantly better assisted reproduction outcomes such as fertilization rate,excellent embryo rate,implantation rate,pregnancy rate and abortion rate,and the differences were statistically significant(P<0.05).Conclusion Adding sperm agonist SperMagic to ICSI can significantly increase sperm motility and improve pregnancy outcome.