桂枝茯苓丸合肾气丸对急性缺血性中风的影响

Effect of Guizhi Fuling Pill and Shenqi Pill on Acute Ischemic Stroke

目的:探讨桂枝茯苓丸合肾气丸对肾虚血瘀型急性缺血性中风侧支循环及临床疗效的影响。方法:选取江门市五邑中医院2018年10月至2020年5月期间收治的60例肾虚血瘀型急性缺血性中风患者,按照随机数字表法分成观察组与对照组,各30例。对照组给予常规西药治疗,观察组加用桂枝茯苓丸合肾气丸,比较两组患者的侧支循环、神经缺损程度、生活能力。结果:治疗前两组患者的脉动指数(PI)、阻力指数(RI)比较,差异无统计学意义(P>0.05);治疗后两组患者的PI、RI均有不同程度下降,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者的美国国立卫生研究院卒中量表(NIHSS)评分比较,差异无统计学意义(P>0.05);治疗后两组患者的NIHSS评分均有不同程度下降,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者的巴塞尔指数(BI)、改良Rankin修订量表(mRS)评分比较,差异无统计学意义(P>0.05);治疗后两组患者的BI评分均有不同程度提高,mRS评分不同程度下降,且观察组BI评分高于对照组,mRS评分低于对照组,差异具有统计学意义(P<0.05)。结论:桂枝茯苓丸合肾气丸用于肾虚血瘀型急性缺血性中风患者疗效较好,可改善患者侧支循环,减少神经缺损,并提高生活能力。

Objective To explore the effects of Guizhi Fuling pill and Shenqi Pill on collateral circulation and clinical efficacy of acute ischemic stroke with kidney deficiency and blood stasis.Methods 60 patients with acute ischemic stroke of kidney deficiency and blood stasis type treated in Jiangmen Wuyi Hospital of Traditional Chinese Medicine from October 2018 to may 2020 were randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Guizhi Fuling pill and Shenqi Pill on the basis of the control group.The collateral circulation,nerve defect and living ability of the two groups were compared.Results There was no significant difference in pulsation index(PI)and resistance index(RI)between the two groups before treatment(P>0.05).After treatment,the PI and RI of the two groups decreased to varying degrees,and these indexes of the observation group were lower than those of the control group(P<0.05);There was no significant difference in NIHSS score between the two groups before treatment(P>0.05).After treatment,NIHSS score of the two groups decreased in varying degrees,and NIHSS score the observation group was lower than that of the control group,the difference was statistically significant(P<0.05);There was no significant difference in the scores of Barthel index(BI)and modified Rankin revised scale(mRS)between the two groups before treatment(P>0.05).After treatment,the BI score of the two groups increased in varying degrees,and the mRS score decreased in varying degrees.The BI score of the observation group was higher than that of the control group,and the mRS score was lower than that of the control group(P<0.05).Conclusion Guizhi Fuling pill and Shenqi Pill are effective in patients with acute ischemic stroke of kidney deficiency and blood stasis type.They can improve collateral circulation,reduce nerve defect,and improve living ability.