盐酸氨溴索联合鼻塞气道正压通气治疗新生儿呼吸衰竭

Ambroxol Hydrochloride Combined with Nasal Positive Airway Pressure Ventilation in the Treatment of Newborns with Respiratory Failure

目的:探讨盐酸氨溴索联合鼻塞式气道正压通气在呼吸衰竭的新生儿治疗中的作用。方法:选取惠东县人民医院2017年1月至2020年1月期间收治的60例有呼吸衰竭的新生儿,用计算机随机分为对照组与观察组,各30例。对照组实施盐酸氨溴索治疗,在此基础上观察组加用鼻塞式气道正压通气治疗,比较两组患儿治疗效果。结果:观察组患儿治疗总有效率为96.67%,高于对照组的70.00%,差异具有统计学意义(P<0.05)。治疗前两组患儿的动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、氢离子浓度指数(pH)比较,差异无统计学意义(P>0.05);治疗后观察组患儿的PaO_(2)高于对照组,PaCO_(2)、pH均低于对照组,差异具有统计学意义(P<0.05)。观察组患儿不良反应发生率为6.67%,低于对照组的30.00%,差异具有统计学意义(P<0.05)。结论:针对有呼吸衰竭症的新生儿,在治疗中选择盐酸氨溴索联合鼻塞式气道正压通气,可纠正患儿低氧血症,减少机械通气降低费用,改善预后,且不良反应少。

Objective To explore the clinical effect of ambroxol hydrochloride combined with nasal positive airway pressure ventilation in the treatment of newborns with respiratory failure.Methods 60 newborns with respiratory failure treated in Huidong County People's Hospital from January 2017 to January 2020 were randomly divided into control group and observation group with 30 cases in each group.The control group was treated with ambroxol hydrochloride.On this basis,the observation group was treated with nasal positive airway pressure ventilation,and the trentment effects of the two groups were compared.Results The total effective rate of the observation group was 96.67%,higher than 70.00%of the control group,the difference was statistically significant(P<0.05);There was no significant difference in arterial oxygen partial pressure(PaO_(2)),arterial carbon dioxide partial pressure(PaCO_(2))and pH between the two groups before treatment(P>0.05).After treatment,PaO_(2) in the observation group was higher than that in the control group,PaCO_(2) and pH were lower than those in the control group,the differences were statistically significant(P<0.05);The incidence of adverse reactions in the observation group was 6.67%,lower than 30.00%in the control group(P<0.05).Conclusion For newborns with respiratory failure,ambroxol hydrochloride combined with nasal positive airway pressure ventilation can correct hypoxemia,reduce mechanical ventilation,reduce costs,improve prognosis and have fewer adverse reactions.