红花注射液联合尼可地尔对心肌梗死后心绞痛患者血液流变学的影响

Effect of Honghua injection combined with Nicorandil on hemorheology of patients with angina pectoris after myocardial infarction

目的 研究红花注射液联合尼可地尔对心肌梗死后心绞痛患者血液流变学的影响。方法 选取2017年1月至2019年12月于佳木斯市中心医院住院治疗的84例心肌梗死后心绞痛患者为研究对象,随机分为试验组(n=42)与对照组(n=42),对照组给予尼可地尔治疗,试验组在对照组的基础上给予红花注射液。观察并记录两组患者治疗后的效果,测定血液流变学变化,统计比较两组心电图改变,记录不良反应的发生。结果 试验组总有效率明显高于对照组(P<0.001);治疗后,两组患者血浆黏度、血小板聚集率、纤维蛋白原、全血黏度均降低,但试验组降低更明显(P<0.001);治疗前两组患者24 h缺血发作次数、ST段最大下降幅度及ST段下降时间比较,差异无统计学意义(P>0.05);治疗后,两组患者24 h缺血发作次数、ST段最大下降幅度及ST段下降时间均较治疗前降低,且试验组更明显(P<0.001);试验组总不良反应发生率为16.66%,对照组为11.90%,差异无统计学意义(P>0.05)。结论 红花注射液联合尼可地尔治疗心肌梗死后心绞痛患者疗效较好,可改善血液流变学指标,未增加不良反应的发生,对指导临床治疗有一定作用。

Objective To investigate the effect of Honghua combined with Nicorandil on hemorheology of patients with angina pectoris after myocardial infarction.Methods A total of 84 patients with angina pectoris after myocardial infarction who were hospitalized in Jiamusi Central Hospital from January 2017 to December 2019 were selected as the research subjects,and randomly divided into the experimental group and the control group.The control group was treated with Nicorandil,and the experimental group was given Honghua on the basis of the control group.After treatment,the effect of the two groups of patients was observed and recorded;the changes of hemorheology were measured;the ECG changes of the two groups were statistically compared;the occurrence of adverse reactions was recorded.Results The total effective rate of the experimental group was significantly higher than that of the control group(P<0.001).After treatment,the plasma viscosity,platelet aggregation rates,fibrinogen and whole blood viscosity were decreased in both groups,but the decreases were more significant in the experimental group(P<0.001).Before treatment,the numbers of ischemic attacks at 24 h,the maximum declines of ST segment and the time of ST segment decline were compared between the two groups,and no statistically significant differences were observed(P>0.05).After treatment,the numbers of ischemic attacks at 24 h,the maximum declines of ST segment and the time of ST segment decline in the two groups were lower than those before treatment,and the decreases were more significant in the experimental group(P<0.001).The total incidence of the adverse reaction in the experimental group was 16.66%,and that in the control group was 11.90%,with no statistically significant difference between the two groups(P>0.05).Conclusion Honghua combined with Nicorandil has a good efficacy in the treatment of patients with angina pectoris after myocardial infarction,which can improve hemorheology indexes without increasing the occurrence of adverse reactions,and has a certain role in guiding clinical treatment.