冠心病患者血清Sestrin2水平及其与基质金属蛋白酶及炎症因子的关系

Serum Sestrin2 level and its relationship with matrix metalloproteinase and inflammatory factors in patients with coronary heart disease

目的探讨冠心病患者血清Sestrin2水平及其与基质金属蛋白酶(MMP)及炎症因子的关系。方法选择123例冠心病患者,根据疾病类型分为急性冠状动脉综合征(ACS)组69例和慢性心肌缺血综合征(CIS)组54例,另选择109例体检者为对照组。比较不同疾病类型、冠状动脉病变支数(单支组、双支组、多支组)、冠状动脉病变程度(轻度组、中度组、重度组)的冠心病患者,以及冠心病患者与对照组的血清Sestrin2、MMP-2、MMP-9、白细胞介素(IL)-6、IL-1β水平。分析冠心病患者血清Sestrin2水平与Gensini评分及血清MMP-2、MMP-9、IL-6、IL-1β水平的相关性。结果 ACS组、CIS组患者血清Sestrin2、MMP-2、MMP-9、IL-6、IL-1β水平高于对照组,且ACS组患者上述指标水平高于CIS组(均P<0.05)。单支组、双支组、多支组,以及轻度组、中度组、重度组患者的血清Sestrin2、MMP-2、MMP-9、IL-6、IL-1β水平依次升高(均P<0.05)。冠心病患者血清Sestrin2水平与Gensini评分及血清MMP-2、MMP-9、IL-6、IL-1β水平呈正相关(均P<0.05)。结论冠心病患者血清Sestrin2水平升高,并与冠状动脉病变程度密切相关;Sestrin2可能通过调控血清MMP-2、MMP-9、IL-6、IL-1β水平参与冠状动脉病变过程。

Objective To investigate serum Sestrin2 level and its relationship with matrix metalloproteinase(MMP) and inflammatory factors in patients with coronary heart disease.Methods A total of 123 patients with coronary heart disease selected were divided into acute coronary syndrome(ACS) group(n=69) and chronic myocardial ischemia syndrome(CIS) group(n=54) according to the classification of the disease. In addition, 109 check-up individuals were enrolled as control group. Serum Sestrin2, MMP-2, MMP-9, interleukin(IL)-6, and IL-1β levels were compared between patients with different types of coronary heart disease, between coronary heart disease patients with different numbers of coronary artery lesions(i.e. single-vessel group, two-vessel group and multiple-vessel group), or between coronary heart disease patients with different severities of coronary artery lesions(i.e. mild group, moderate group and severe group);and the aforementioned levels of patients with coronary heart disease were compared with those of the control group. The correlations of serum Sestrin2 level with Gensini score and serum levels of MMP-2, MMP-9, IL-6, and IL-1β were analyzed in patients with coronary heart disease.Results The serum levels of Sestrin2, MMP-2, MMP-9, IL-6, and IL-1β in the ACS and CIS groups were higher than those in the control group, and the aforementioned indicators in the ACS group were higher than those in the CIS group(all P<0.05). Serum Sestrin2, MMP-2, MMP-9, IL-6, and IL-1β levels increased in the sequence of the single-vessel group, the two-vessel group and the multiple-vessel group, and also increased in the sequence of the mild group, the moderate group and the severe group(all P<0.05). Serum Sestrin2 level positively correlated with the Gensini score and serum levels of MMP-2, MMP-9, IL-6, and IL-1β in patients with coronary heart disease(all P<0.05).Conclusion Serum Sestrin2 level is elevated in patients with coronary heart disease and closely correlates with the severity of coronary artery lesion. Sestrin2 may be involved in the process of coronary lesion development by regulating serum levels of MMP-2, MMP-9, IL-6, and IL-1β.