卡瑞利珠单抗引起的反应性毛细血管增生症二例

Reactive cutaneous capillary endothelial proliferation caused by PD-1 inhibitor camrelizumab: two cases report

2例患者分别在首次使用卡瑞利珠单抗2周和3周后出现头面部、躯干和四肢皮肤的血管赘生物,部分皮损伴破溃出血,遂行手术切除,术后行组织病理活检示:肉芽组织型血管瘤。诊断:反应性毛细血管增生症。

Two patients with lung cancers presented with cutaneous capillary endothelial proliferation on the head, face, trunk, and extremities after the first treatment with camrelizumab for 2 or 3 weeks. Some lesions which were accompanied with ulceration and bleeding were treated with surgical resections. The histological feature was in accordance with granulomatous hemangioma. The diagnosis of reactive cutaneous capillary endothelial proliferation was made.