吲哚菁绿介导的光动力疗法对牙周炎疗效的Meta分析

The Effect of Indocyanine Green-mediated Photodynamic Therapy in Treating Periodontitis:A Meta-analysis

目的:评价吲哚菁绿(Indocyanine green,ICG)介导的光动力疗法(Photodynamic therapy,PDT)(ICG-PDT)在治疗慢性牙周炎中的疗效。方法:检索EMBASE、Cochrane Library、Medline/PubMed、中国期刊全文数据库(CNKI)和中国生物医学文献数据库(CBM),截止时间2020年7月28日。筛选研究ICG-PDT治疗慢性牙周炎的随机对照试验(RCT),实验组采用ICG-PDT疗法,对照组采用单纯SRP治疗。结果:共纳入8项RCT,312例受试者。治疗3个月后,ICG-PDT组的探诊深度(PPD)、菌斑指数(PI)、临床附着丧失(CAL)改善均显著优于对照组,差异有统计学意义(P<0.05),但是在相对附着水平(RAL)、探诊出血(BOP)、牙龈退缩(GR)方面与对照组相比无明显差异(P>0.2);治疗6个月后,ICG-PDT组的PI、CAL改善情况均显著优于对照组,差异有统计学意义(P<0.05)。结论:ICG-PDT辅助SRP治疗慢性牙周炎效果显著优于传统的SRP治疗。

Objective To evaluate the efficacy of indocyanine green(ICG)mediated photodynamic therapy(PDT)(ICG-PDT)in treating chronic periodontitis.Methods The EMBASE,Cochrane library,Medline/PubMed,CNKI,and CBM databases were searched up to 28th July 2020.Only randomized controlled trials(RCTs)were included.The test group received ICG-PDT combined with scaling and root planning(SRP),while the control group only received SRP.Results Eight RCTs involving 312 participants were included.The ICG-PDT group showed greater improvements referring probing pocket depth(PPD),plaque index(PI),clinical attachment loss(CAL)after 3 months than that of the control group(P<0.05).However,no significant differences between groups were observed for relative attachment level(RAL)、bleeding on probing(BOP)and gingival recession(GR)(P>0.2).After 6mouths,ICG-PDT group showed greater improvements referring PI,CAL when compared with the control group(P<0.05).Conclusion ICG mediated PDT provides additional benefits in treating chronic periodontitis than SRP alone.