摘要
近年来,随着碳青霉烯类抗生素的广泛使用,儿童中耐碳青霉烯类肠杆菌目细菌(CRE)感染的病例越来越常见,且往往临床结局不良。由于儿童特殊的药代动力学/药效动力学(PK/PD)特征,多数抗CRE药物缺乏在这一群体中的临床应用经验,儿科医生在治疗CRE时面临巨大挑战。本文收集对儿童CRE感染的现有认识,就其流行病学、耐药机制以及最新的治疗策略进行综述,旨在为临床用药提供参考。
In recent years,with the widely application of carbapenems,carbapenem-resistant Enterobacterales(CRE)infection is increasingly prevalent in children,and are often associated with poor clinical outcomes.Due to the specific pharmacokinetic/pharmacodynamic(PK/PD)characteristics of children,most anti-CRE antimicrobial agents lack clinical application experience in children,and pediatricians face huge challenge in the treatment of CRE.In this paper,the existing knowledge of CRE infection in children is collected,epidemiology,antimicrobial resis-tance mechanisms and the latest treatment strategies are reviewed,so as to provide a reference for clinical medication.
作者
周冉
方玉婷
苏丹
沈爱宗
ZHOU Ran;FANG Yu-ting;SU Dan;SHEN Ai-zong(Department of Pharmacy,Anhui Provincial Hospital,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2022年第2期204-208,共5页
Chinese Journal of Infection Control
基金
中华医学会临床药学分会吴阶平医学基金会科研基金项目(NO.LCYX-Q009)
中国科学技术大学质量工程项目(2019xjyxm097)。
关键词
碳青霉烯类
耐药
肠杆菌目细菌
治疗策略
儿童
carbapenem
antimicrobial resistance
Enterobacterales
treatment strategy
child
