摘要
烟酰胺腺嘌呤二核苷酸(NAD^(+))是细胞内一种重要的辅助调节因子,NAD^(+)代谢紊乱与细胞功能损伤、生理改变及疾病的发生发展密切相关。在衰老、听力障碍、心脏损伤等代谢性和年龄相关性疾病的发生过程中都伴随着NAD^(+)水平下降,因此,通过补充恢复NAD^(+)水平可为这些疾病的治疗提供了一种新思路。
Nicotinamide adenine dinucleotide(NAD^(+))is an important coregulatory factor in cells.The metabolic disorder of NAD^(+)is closely related to the damage of cell function,physiological changes and the occurrence and development of diseases.The decrease of NAD^(+)level is accompanied by the occurrence of metabolic and age-related diseases such as aging,hearing impairment and cardiac damage.Therefore,it provides a new idea for the treatment of these diseases by supplementing and restoring the level of NAD^(+).
作者
何盛梅
赵厚育
HE Sheng-mei;ZHAO Hou-yu(Guizhou Medical University, Guiyang 550004;Department of Otorhinolaryngology Head and Neck Surgery,the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China)
出处
《基础医学与临床》
2022年第2期306-310,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81860387)
贵州省科技计划项目(黔科合基础[2020]1Y311)
贵州医科大学附属医院2020年国家自然科学基金培育项目(I-2020-10)。
关键词
烟酰胺腺嘌呤二核苷酸
代谢
衰老
听力障碍
心脏损伤
nicotinamide adenine dinucleotide
metabolism
aging
hearing impairment
cardiac damage
