时钟基因PER调控血压的研究进展

Advances in research on blood pressure regulation by clock gene PER

时钟基因的异常表达与血压昼夜节律紊乱以及高血压的发生发展密切相关。本文总结了时钟基因周期基因(PER)与血压昼夜节律的关系,在与血压调控相关的外周组织器官中PER的异常表达对血压的影响以及高血压时间疗法的研究进展。旨在为高血压的临床诊治和预后提供新思路。

The abnormal expression of clock genes is closely related to the circadian rhythm of blood pressure and to the occurrence and development of hypertension.This article summarizes the relationship between the clock gene period(PER)and the circadian rhythm of blood pressure,the influence of abnormal expression of PER in peripheral tissues and organs related to blood pressure regulation on blood pressure,and the research progress in the field of hypertension chronotherapy.The author hopes to provide new ideas for the clinical diagnosis,treatment and prognosis of hypertension.