半夏白术天麻汤合温胆汤加减治疗痰湿壅盛型原发性高血压临床研究

Clinical Study on Pinellia and White Atractylodes and Gastrodia Decoction and Modified Gallbladder-Warming Decoction in the Treatment of Essential Hypertension with Excessive Phlegm and Dampness Syndrome

目的:观察半夏白术天麻汤合温胆汤加减治疗痰湿壅盛型原发性高血压的临床疗效。方法:将98例原发性高血压痰湿壅盛证患者按照随机数字表法分为治疗组和对照组,每组各49例。对照组给予硝苯地平缓释片治疗,治疗组给予半夏白术天麻汤合温胆汤加减治疗。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、血压[收缩压(systolic pressure,SBP)、舒张压(diastolic pressure,DBP)]、血脂[三酰甘油(triacylglycerol,TG)、血清总胆固醇(total cholesterol,TC)]变化情况。结果:两组患者治疗后头痛、眩晕、胸闷、呕吐痰涎等积分低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。治疗组有效率为95.92%,高于对照组的79.59%,差异具有统计学意义(P<0.05)。两组患者治疗后SBP、DBP、TG、TC低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:半夏白术天麻汤合温胆汤加减治疗痰湿壅盛型原发性高血压,可改善患者临床症状,有效控制血压,降低血脂水平。

Objective:To observe the clinical curative effect of Pinellia and White Atractylodes and Gastrodia Decoction and Modified Gallbladder-Warming Decoction on essential hypertension with excessive phlegm dampness syndrome.Methods:A total of 98 patients with essential hypertension with excessive phlegm dampness syndrome were randomly divided into the treatment group and the control group,with 49 cases in each group.The control group was treated with Nifedipine Sustained-Release Tablets,while the treatment group was treated with Pinellia and White Atractylodes and Gastrodia Decoction and Modified Gallbladder-Warming Decoction.The clinical efficacy,the incidence of adverse reactions and the changes of TCM syndrome score,blood pressure[including systolic pressure(SBP),diastolic pressure(DBP)],blood lipid[including triacylglycerol(TG)and total cholesterol(TC)]before and after treatment were compared between the two groups.Results:After treatment,the scores of headache,dizziness,chest tightness,vomiting and sputum salivation in the two groups were lower than those of the same group before treatment,and after treatment,the above indexes in the treatment group were lower than those in the control group,and all the differences were statistically significant(P<0.05).The effective rate in the treatment group was 95.92%,which was higher than 79.59%in the control group,and the difference was statistically significant(P<0.05).After treatment,SBP,DBP,TG and TC in the two groups were lower than those of the same group before treatment,and the above indexes of the treatment group were lower than those in the control group,and all the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Pinellia and White Atractylodes and Gastrodia Decoction and Modified Gallbladder-Warming Decoction in the treatment of essential hypertension with excessive phlegm dampness syndrome can improve patients′clinical symptoms,effectively control their blood pressure and reduce blood lipid level.