血浆网膜素1水平与2型糖尿病患者代谢清除率的关系

Relationship between plasma omentin-1 level and metabolic clearance rate in type 2 diabetes mellitus patients

目的探讨血浆网膜素1水平与2型糖尿病(T2DM)患者代谢清除率(MCR)之间的关系。方法选取T2DM患者126例(T2DM组)、体检健康者102名(正常对照组)。检测所有对象网膜素1、空腹血糖、糖化红蛋白(HbA_(lc))、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,计算MCR和胰岛素抵抗指数(HOMR-IR)。根据MCR均值将126例T2DM患者分为高MCR组和低MCR组。采用Pearson相关分析评估各项目的相关性。采用多元逐步回归分析评估MCR和HOMA-IR的影响因素。结果T2DM组血浆网膜素1、MCR水平均低于正常对照组(P<0.01)。低MCR组TC、TG、LDL-C、HbA_(lc)水平及HOMA-IR均高于高MCR组,HDL-C和网膜素1水平均低于高MCR组(P<0.001)。Pearson相关分析结果表明,网膜素1与MCR、HDL-C呈正相关(r值分别为0.589、0.236,P<0.05),MCR与HbA_(lc)、TC、TG呈负相关(r值分别为-0.689、-0.120、-0.420,P<0.05),HOMA-IR与网膜素1呈负相关(r=-0.752,P<0.001),HOMA-IR与TG呈正相关(r=0.265,P<0.05)。多元逐步回归分析结果显示,影响MCR的主要变量为HbA_(lc)及网膜素1,影响HOMA-IR的主要变量为网膜素1。结论T2DM患者血浆网膜素1水平与MCR密切相关,可作为反映机体糖、脂代谢的指标。

Objective To investigate the relationship between plasma omentin-1 level and metabolic clearance rate(MCR)in type 2 diabetes mellitus(T2DM)patients.Methods Totally,126 patients with T2 DM and 102 healthy subjects were enrolled.The levels of plasma omentin-1,fasting blood glucose,glycated hemoglobin A1 c(HbA_(lc)),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)were determined.MCR and homeostasis model assessment for insulin resistance(HOMR-IR)were calculated.According to MCR,126 patients were classified into high MCR group and low MCR group.Pearson correlation analysis was used.Multivariate stepwise regression analysis was used to analyze the influencing factors of MCR and HOMA-IR.Results The plasma omentin-1 and MCR levels in T2DM group were lower than those in healthy control group(P<0.01).Compared with high MCR group,the levels of TC,TG,LDL-C,HbA_(lc) and HOMA-IR were higher,and the levels of HDL-C and plasma omentin-1 were lower in low MCR group(P<0.001).Pearson correlation analysis showed that there were positive correlations between plasma omentin-1 and MCR,HDL-C(r=0.589 and 0.236,respectively,P<0.05),and there were negative correlations between MCR and HbA_(lc),TC,TG(r=-0.689,-0.120 and-0.420,respectively,P<0.05).There was a negative correlation between HOMA-IR and plasma omentin-1(r=-0.752,P<0.001)and a positive correlation between HOMA-IR and TG(r=0.265,P<0.05).The results of multivariate stepwise regression analysis showed that the main variables affecting MCR were HbA_(lc) and plasma omentin-1,and the main variable affecting HOMA-IR was plasma omentin-1.Conclusions There is a positive correlation between plasma omentin-1 and MCR in T2DM patients,which could be used as indicators to reflect the level of glycolipid metabolism.