自拟化痰活血方联合西医对慢性稳定型心绞痛患者血管内皮功能、T淋巴细胞亚群、炎性因子的影响

The influences of the Huatan Huoxue prescription plus Western medicine on vascular endothelial function,T lymphocyte subsets and inflammatory factors in patients with chronic stable angina pectoris

目的:探讨自拟化痰活血方联合西医治疗对慢性稳定型心绞痛患者血管内皮功能、T淋巴细胞亚群、炎性因子的影响。方法:选择116例慢性稳定型心绞痛痰阻血瘀证患者作为研究对象,根据随机数字表法,将116例患者分为观察组(57例)和对照组(59例),对照组患者予以常规西医治疗,观察组患者予以自拟化痰活血方联合西医治疗,对比分析两组患者的血管内皮功能指标、T淋巴细胞亚群及炎性因子水平变化情况,并比较两组患者的临床疗效。结果:治疗后,观察组患者的血管内皮功能指标、T淋巴细胞亚群及炎性因子水平改善程度均显著优于对照组,临床总有效率显著高于对照组,均P<0.05。结论:在稳定型心绞痛痰阻血瘀证患者采用自拟化痰活血方联合西医治疗可有效提高临床疗效,可能与其改善内皮功能,调节免疫应答有关。

Objective:To investigate the effects of the Huatan Huoxue prescription(化痰活血方)plus Western medicine on vascular endothelial function,T lymphocyte subsets and inflammatory factors in patients with chronic stable angina pectoris.Methods:116 patients with the phlegm obstruction and blood stasis syndrome chronic stable angina pectoris were selected as the research objects.According to the random number table method,all the patients were divided into the observation group(57 cases)and the control group(59 cases).Patients in the control group were treated in conventional Western medicine,and in the observation group were treated with the Huatan Huoxue prescription plus Western medicine.Results:After treatment,the improvement of vascular endothelial function indexes,T lymphocyte subsets and inflammatory factor levels in the observation group was significantly better than those in the control group,and the total efficiency in the observation group was significantly higher than that in the control group,all P<0.05.Conclusion:Treating the phlegm obstruction and blood stasis syndrome chronic stable angina pectoris with the Huatan Huoxue prescription plus Western medicine can effectively improve clinical efficacy,which may be related to improving the patient’s endothelial function and regulating immune response.