丝裂霉素分子内转化化合物的毒性研究

The toxicity research for intramolecular adduct compound of mitomycin

目的对丝裂霉素分子内转化化合物白丝裂霉素进行毒性研究。方法对SD大鼠静脉注射给予320μg/kg和800μg/kg含有不同浓度白丝裂霉素的丝裂霉素,每间隔2 d给药一次,共给药5次;各组动物于D15麻醉采样安乐死后进行大体解剖以及组织病理学检查。结果在丝裂霉素320μg/kg和800μg/kg剂量下,白丝裂霉素剂量的增加对丝裂霉素SD大鼠毒性反应程度未见增大,也未见新的毒性反应或毒性靶器官。结论在临床使用的丝裂霉素配伍溶液中产生的白丝裂霉素不会引入更多的风险。

Objective To evaluate the toxicity of albomitomycin which is intramolecular adduct compound of mitomycin.Methods SD rats were given 320μg/kg and 800μg/kg i.v.mitomycin containing different concentrations of albomitomycin,once every 2 days,total 5 times.Body anatomy and histological pathology examination were carried out after euthanasia at the 15 th day.Results At doses of 320μg/kg and 800μg/kg,the increase in the dose of albomtiomycin did not increase the toxic response to SD rats,nor did there be any new toxic reactions or toxic target organ.Conclusion The albomitomycin induced in the mitomycin constituted solution will not increase additional risk.