枸杞多糖通过调节免疫在肿瘤免疫治疗中的应用前景分析

Application Prospect of LBP on Tumor Immunotherapy by Regulating Immunity

以PD-1/PD-L1单抗为代表的肿瘤免疫治疗是目前为止最具前景的肿瘤治疗方法,但是还需要寻找新的策略以提高临床疗效。枸杞多糖是中药枸杞的主要活性成分,具有调节淋巴细胞、树突状细胞、巨噬细胞、红细胞和NK细胞等免疫细胞功能的作用。文献报道该多糖可以通过TLR受体激活树突状细胞和巨噬细胞,进而影响淋巴细胞的功能。基于此,人们发现将该多糖应用于多种动物肿瘤模型治疗有良好效果,并发现其在人体肿瘤放化疗中具有减毒增效的作用。最新的研究发现枸杞多糖对小鼠肾细胞癌和肝癌的免疫治疗具有增效作用。这些研究结果表明枸杞多糖通过调节免疫在肿瘤免疫治疗中具有良好的应用前景。

Tumor immunotherapy,represented by PD-1/PD-L1 monoclonal antibody,is by far the most promising tumor therapy,but new strategies are still needed to improve the clinical efficacy.Lycium barbarum polysaccharide(LBP)is the main active ingredient of Lycium barbarum,which can regulate the function of immune cells,such as lymphocytes,dendritic cells,macrophages,erythrocytes and NK cells.It has been reported that LBP can activate dendritic cells and macrophages through TLR receptors,and then affect the function of lymphocytes.Based on this,it has been found that LBP has a good effect in the treatment of a variety of animal tumor models;it also has the effect of reducing toxicity and increasing efficacy in human tumor therapy of radiotherapy and chemotherapy.Recent studies have shown that LBP has a synergistic effect on the immunotherapy of renal cell carcinoma and hepatocellular carcinoma in mice.These results indicate that LBP has a good application prospect in tumor immunotherapy by regulating immunity.