利拉鲁肽结合二甲双胍对胰岛素抵抗2型糖尿病患者血糖控制效果的影响

Effect of liraglutide combined with metformin on blood sugar control of patients with insulin-resistant type 2 diabetes mellitus

目的探讨利拉鲁肽结合二甲双胍对胰岛素抵抗2型糖尿病(T2DM)患者血糖控制效果的影响。方法选取2019年1月至2021年6月收治的100例胰岛素抵抗T2DM患者作为研究对象,将其随机分为对照组(50例,二甲双胍)和观察组(50例,利拉鲁肽+二甲双胍)。比较两组的血糖、胰岛素功能指标、腹腔内脂肪面积(VFA)、血清指标及不良反应发生情况。结果治疗后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、VFA均低于对照组,空腹C肽(FC-P)水平高于对照组(P<0.05)。治疗后,观察组的同型半胱氨酸(Hcy)、胱抑素C(CysC)、超敏C反应蛋白(hs-CRP)水平均低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论利拉鲁肽结合二甲双胍治疗胰岛素抵抗T2DM,能有效改善患者的血糖、胰岛素功能指标、VFA,提升抗氧化能力,且安全性高,值得临床推广和应用。

Objective To investigate the effect of liraglutide combined with metformin on blood sugar control of patients with insulin-resistant type 2 diabetes mellitus(T2 DM).Methods A total of 100 patients with insulin-resistant T2 DM admitted from January 2019 to June 2021 were selected as the research subjects,and the patients were randomly divided into control group(50 cases,metformin) and observation group(50 cases,liraglutide + metformin).The blood glucose,insulin function indexes,visceral fat area(VFA),serum indexes and occurrence of adverse reactions were compared between the two groups.Results After treatment,the fasting blood glucose(FPG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1 c),homeostasis model insulin resistance index(HOMA-IR) and VFA in the observation group were lower than those in the control group,fasting C-peptide(FC-P) level was higher than that in the control group(P<0.05).After treatment,the levels of homocysteine(Hcy),cystatin C(CysC),high-sensitivity C-reactive protein(hs-CRP) in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Liraglutide combined with metformin in the treatment of insulin-resistant T2 DM can effectively improve the blood glucose,insulin function indexes and VFA in patients,enhance the antioxidant capacity,and has high safety,which is worthy of clinical promotion and application.