血必净注射液对大肠癌肠梗阻术后并发脓毒症患者炎症反应、凝血功能、血流动力学、免疫功能、血栓弹力指标的影响

Effects of Xuebijing injection on inflammatory response,coagulation function,hemodynamics,immune function and thromboelasticity indexes in patients with sepsis after intestinal obstruction surgery of colorectal cancer

目的探究血必净注射液治疗大肠癌肠梗阻术后并发脓毒症患者的临床效果。方法选取本院2018年1月至2020年1月收治的60例大肠癌肠梗阻术后并发脓毒症患者为研究对象,遵循随机分组原则将其分为对照组和观察组,各30例。对照组开展常规治疗,观察组在对照组基础上给予血必净注射液治疗。比较两组的治疗效果。结果治疗后,两组的TNF-α、IL-6、PCT、CRP水平均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的APTT、PT、TT均缩短,FIB水平均升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的MAP、SpO_(2)、CI均升高,HR降低,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为96.67%,高于对照组的76.67%,差异具有统计学意义(P<0.05)。治疗后,两组的IgM、IgA、IgG水平均较治疗前升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的R值降低,α角、MA值增大,且观察组优于对照组,差异具有统计学意义(P<0.05);治疗前、后,两组的K值无显著差异(P>0.05)。结论采用血必净注射液治疗大肠癌肠梗阻术后并发脓毒症患者效果显著,能有效减轻患者的炎症反应,改善其凝血功能、血流动力学、免疫功能以及血栓弹力指标,具有积极的临床价值。

Objective To explore the clinical effect of Xuebijing injection in the treatment of patients with sepsis after intestinal obstruction surgery of colorectal cancer.Methods Sixty patients with sepsis after intestinal obstruction surgery of colorectal cancer treated in our hospital from January 2018 to January 2020 were selected as the research objects and divided into control group and observation group according to the principle of random grouping,with 30 cases in each group.The control group was given routine treatment,and the observation group was treated with Xuebijing injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of TNF-α,IL-6,PCT and CRP in the two groups were lower than those before treatment,those of the observation group were lower than the control group,and the differences were statistically significant(P <0.05).After treatment,APTT,PT and TT shortened and FIB level increased in both groups,those of the observation group were better than the control group,and the differences were statistically significant(P <0.05).After treatment,MAP,SpO2 and CI increased and HR decreased in both groups,those of the observation group were better than the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.67%,which was higher than 76.67% in the control group,and the difference was statistically significant(P <0.05).After treatment,the levels of IgM,IgA and IgG in the two groups were higher than those before treatment,those of the observation group were higher than the control group,and the differences were statistically significant(P <0.05).After treatment,the R value of the two groups decreased,the α angle and MA value increased,those of the observation group were better than the control group,and the differences were statistically significant(P <0.05);there was no significant difference in K value between the two groups before and after treatment(P >0.05).Conclusion Xuebijing injection is effective in the treatment of patients with sepsis after intestinal obstruction surgery of colorectal cancer.It can effectively reduce the inflammatory response,and improve the coagulation function,hemodynamics,immune function and thromboelasticity indexes,with positive clinical value.