真实世界喜炎平注射液治疗儿童肺炎联合用药特征研究

Real-world study on Xiyanping injection combined in the treatment of childhood pneumonia

目的分析真实世界中喜炎平注射液联合用药治疗肺炎患儿的用药特征。方法基于2006年12月1日至2016年6月30日全国29家三级甲等医院信息管理系统(HIS)数据库和实验室(检验科)信息系统(LIS)数据库,采用Apriori算法建立模型和Clementine 12.0进行关联分析,对使用喜炎平注射液的35233例患儿人群特征和联合用药情况进行分析。结果患儿年龄0~3岁(82.83%)占比最大;真实世界中儿童人群使用喜炎平注射液多应用于一般病情;住院天数4~14 d占比最大;喜炎平注射液静脉单次每日给药剂量50~100 mg占比最大;主要用于西医诊断为支气管肺炎,中医诊断主病肺炎喘咳病,主证痰热、风热;喜炎平注射液一般联合氨溴索(美舒咳)黏液溶解药,布地奈德皮质甾体激素类,沙丁胺醇选择性β2-肾上腺素受体促效药,异丙托溴铵抗胆碱能药使用最常见。结论在治疗儿童肺炎患者时常用喜炎平注射液与黏液溶解药、皮质甾体激素类、选择性β2-肾上腺素受体促效药和抗胆碱能药类化学药品联合使用,为临床合理使用喜炎平注射液提供参考。

Objective To analyze the medication characteristics of Xiyanping injection combined in the treatment of children with pneumonia in the real world.Methods Based on HIS and LIS database of hospitalized patients from 29 hospitals in China from December 1,2006 to June 30,2016,the Apriori algorithm was conducted to establish the model and clementine 12.0 was conducted to analyze the characteristics and combination medication of 35233 children who received Xiyanping injection with pneumonia.Results Children aged 0~3 years(82.83%)accounted for the largest proportion;In the real world,Xiyanping injection is mainly used for children with general conditions;The number of days in hospital was 4~14 days;For Xiyanping injection,the single intravenous dose per day was 50~100 mg;The main diagnosis of Western medicine was bronchial pneumonia,and the main diagnosis of Traditional Chinese medicine was pneumonia,asthma and cough,and the main syndromes were phlegm-heat and wind-heat;Xiyanping injection is generally combined with ambroxol(methusol)mucus dissolver,budesonide corticosteroid hormone,salbutamol selectiveβ2-adrenergic receptor stimulant,and ipratropium bromide anticholinergic drug.Conclusion Xiyanping injection is often used in combination with mucolysis drugs,corticosteroid hormones,selectiveβ2-adrenergic receptor promoters and anticholinergic chemicals in the treatment of children with pneumonia to provide a reference for the rational use of Xiyanping injection in clinical practice.