垂体后叶注射液致药品不良反应文献分析

Literature analysis of adverse drug reactions induced by posterior pituitary injection

目的探讨垂体后叶注射液致不良反应的一般规律、特点及相关风险因素,为临床安全用药提供参考。方法以“垂体后叶注射液”“不良反应”等为检索词,检索中国知网(CNKI)、维普网(VIP)及万方数据中建库以来至2019年4月30日报道的涉及垂体后叶注射液所致不良反应的文献资料,按纳入与排除标准共纳入159篇文献,进行资料提取和统计分析。结果垂体后叶注射液不良反应可累及多个系统-器官,以低钠血症、胃肠道损害最为常见,严重者可致低钠性脑病、心跳骤停等。结论重视垂体后叶注射液引发的不良反应,密切防范不良反应的发生,确保临床用药安全。

Objective To study the pattern,characteristics and influencing factors of adverse reactions induced by posterior pituitary injection so as to provide reference for clinical safe medication.Methods Based on such key words as“pituitrin injection”and“adverse reactions”,literature was searched for that was related to the adverse reactions caused by pituitrin injection reported in CNKI,VIP and Wanfang databases between inception and April 30,2019.According to the inclusion and exclusion criteria,159 articles were included for data retrieval and statistical analysis.Results The adverse reactions involved multiple organs and systems.The most common reactions were hyponatremia and gastrointestinal tract damage.In severe cases,hyponatremia encephalopathy and cardiac arrest were likely.Conclusion The adverse reactions caused by posterior pituitary injection deserve attention,and efforts have to be made to guard against the occurrence of adverse reactions to ensure the safety of clinical medication.