平溃饮对溃疡性结肠炎(脾虚血瘀证)患者临床疗效及血清白细胞介素-6、C反应蛋白水平的影响

Effect of Pingkui decoction on clinical efficacy and serum IL-6,CRP levels in patients with ulcerative colitis(spleen deficiency and blood stasis syndrome)

目的:探究中药方剂平溃饮治疗溃疡性结肠炎(Ulcerative Colitis,UC)的临床疗效及对血清炎性因子白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive Protein,CRP)水平的影响。方法:选取自2016年7月-2019年12月于重庆市北碚区中医院就诊的轻度、中度脾虚血瘀证UC患者60例,应用随机数字表法分为美沙拉嗪组和平溃饮组,分别给予美沙拉嗪、平溃饮方剂治疗4周。治疗结束后比较两组患者临床疗效、检测患者的血清IL-6、CRP水平。同时随机抽取健康体检者30例为参考组。结果:临床疗效比较,美沙拉嗪组有效率为83.34%(25/30),平溃饮组有效率为76.67%(23/30);治疗前UC患者血清IL-6、CRP水平均高于参考组(P<0.01),与治疗前比较治疗后患者IL-6、CRP水平均明显降低,差异有统计学意义(P<0.05)。结论:中药方剂平溃饮能提高UC的临床疗效,能够降低血清中促炎性因子IL-6、CRP水平。

Objective:To observe the clinical efficacy of Pingkui decoction(平溃饮)for ulcerative colitis and its effect on serum levels of interleukin-6(IL-6)and C-reactive protein(CRP).Methods:60 patients with mild and moderate ulcerative colitis in Beibei Hospital of traditional Chinese medicine,Chongqing were selected from July 2016 to December 2019.All patients with spleen deficiency and blood stasis syndrome were randomly divided into the mesalazine group and Pingkui decoction by digital table method,and were treated with mesalazine and Pingkui decoction for 4 weeks.After the treatment,the clinical efficacy and serum IL-6 and CRP levels of the two groups were compared.At the same time,30 healthy people were randomly selected as the control group.Results:The effective rate of the mesalazine group was 83.34%(25/30),and that of Pingkui decoction group was 76.67%(23/30).The levels of serum IL-6 and CRP in UC patients before treatment were higher than those in the control group(P<0.01),and the levels of IL-6 and CRP in UC patients after treatment were significantly lower than those before treatment(P<0.05).Conclusion:Pingkui decoction can improve the clinical efficacy of ulcerative colitis,and it can reduce the levels of IL-6 and CRP in serum.