柴胡桂枝干姜汤加味治疗慢性乙型肝炎肝硬化残留黄疸临床观察

Clinical Observation of Modifed Chaihu Guizhi Ganjiang Decoction in Treating Chronic Hepatitis B Liver Cirrhosis and Residual Jaundice

[目的]观察柴胡桂枝干姜汤加味治疗慢性乙型肝炎肝硬化残留黄疸的疗效。[方法]将符合纳入标准的64例慢性乙型肝炎肝硬化残留黄疸患者按开放式随机对照试验设计原则分为两组,各32例。对照组常规予西医综合治疗;治疗组在对照组治疗的基础上,加用柴胡桂枝干姜汤加味汤药治疗,两组疗程均为4周。观察两组治疗前后肝功能相关指标、凝血酶原活动度(PTA)及临床疗效。[结果]治疗后两组肝功能及PTA改善效果均优于治疗前;治疗后治疗组肝功能及PTA改善效果显著优于对照组,差异具有统计学意义(P<0.05)。治疗组总有效率为90.6%,对照组为62.5%,两组疗效差异具有统计学意义(P<0.05)。[结论]加用柴胡桂枝干姜汤加味治疗慢性乙型肝炎肝硬化残留黄疸优于西医综合治疗,值得临床推广。

[Objective]To observe the curative effect of modified Chaihu Guizhi Ganjiang Decoction on chronic hepatitis B liver cirrhosis and residual jaundice.[Methods]Sixty-four patients with chronic hepatitis B liver cirrhosis and residual jaundice were divided into 2 groups according to the principle of randomized controlled trial design,with 32 cases in each group.The control group was treated with comprehensive treatment of western medicine;the treatment group was treated with modified Chaihu Guizhi Ganjiang Decoction on the basis of the treatment of the control group.The course of treatment in both groups was 4 weeks.The related indexes of liver function,prothrombin time activity(PTA)and clinical efficacy were observated before and after treatment in the two groups.[Results]After treatment,the improvement effect of liver function and PTA in the two groups was better than that before treatment;the improvement effect of liver function and PTA in the treatment group was significantly better than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate was 90.6% in the treatment group and 62.5% in the control group.The difference between the two groups was statistically significant(P<0.05).[Conclusion]Adding modified Chaihu Guizhi Ganjiang Decoction to treat chronic hepatitis B liver cirrhosis with residual jaundice is better than the comprehensive treatment of western medicine,and it is worthy of clinical promotion.