抗氧化剂改善卵母细胞线粒体功能和不孕女性生育结局的研究进展

Research Progress of Antioxidants Supplement on Improvement of Oocyte Mitochondrial Function and Reproductive Outcomes in Infertile Women

线粒体是体内产生能量的工厂,在产生三磷酸腺苷(adenosine triphosphate,ATP)的同时还会产生大量的活性氧(reactive oxygen species,ROS)。过多的ROS可诱导氧化应激并最终导致线粒体功能障碍。卵母细胞线粒体功能障碍可导致卵母细胞质量下降,影响胚胎发育和妊娠结局。最新的动物实验和临床试验均表明,白黎芦醇、辅酶Q10、褪黑素、叶酸和维生素E等抗氧化剂可通过改善线粒体功能、促进线粒体生物合成来提高人类卵母细胞和胚胎质量,改善多囊卵巢综合征、早发性卵巢功能不全等不孕患者的生育结局。辅助生殖助孕的患者在周期前口服抗氧化剂或在体外未成熟卵母细胞培养液中加入抗氧化剂可能改善助孕结局。综述抗氧化剂最新的动物实验结果和辅助生殖临床应用剂量、途径和效果。

Mitochondria,as a factory that produces energy in the body,produce adenosine triphosphate(ATP)while also generate high amounts of reactive oxygen species(ROS).ROS at the high level is detrimental,leading to oxidative stress and ultimately to mitochondrial dysfunction.Oocyte mitochondrial dysfunction may also lead to poor oocyte quality and embryo development,and poor pregnancy outcomes.The newest animal experiments and clinical trials suggest that antioxidants such as resveratrol,coenzyme Q10,melatonin,folic acid and vitamin E may improve human oocyte and embryo quality via improving oocyte mitochondrial function.Antioxidants can improve the reproductive outcomes of patients with polycystic ovarian syndrome and premature ovarian insufficiency by promoting mitochondrial biogenesis.It is suggested that oral antioxidants supplement before assisted reproductive cycles or the antioxidants added into culture medium of in vitro immature oocytes may improve assisted reproductive outcomes.We reviewed the outcomes of antioxidants applied in animal experiments and clinical trials including its dose and administration route.